Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.34 |
| ▸ | MTOR | P42345 | 8/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469774 | 0.84 | NUDT1 (0.49) | KDM4EPIK3CADHFRALDH1A1MAPT | |
| SCHEMBL4462891 | 0.84 | IGF1R (0.43) | KDM4EPIK3CAPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4457078 | 0.69 | IGF1R (0.41) | ABL1BCR | |
| SCHEMBL4457348 | 0.69 | HRH3 (0.35) | — | |
| SCHEMBL4463994 | 0.68 | IGF1R (0.31) | — | |
| SCHEMBL4469769 | 0.67 | NUDT1 (0.46) | KDM4EPIK3CAMTORDHFRMAPT | |
| SCHEMBL4457095 | 0.62 | DRD2 (0.42) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL26608009 | 0.61 | ABL1 (0.50) | KDM4ENPC1RAB9APIK3CAPIK3CB | |
| SCHEMBL459183 | 0.60 | PPARA (0.43) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL603299 | 0.60 | HRH4 (0.51) | NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |