Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.34 |
| ▸ | MTOR | P42345 | 7/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4457078 | 0.86 | IGF1R (0.41) | IGF1RABL1BCRBMPR1BPLK4 | |
| SCHEMBL4469769 | 0.84 | NUDT1 (0.46) | IGF1RPIK3CAMTORKDM4EMAPT | |
| SCHEMBL4462898 | 0.84 | KDM4E (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGMTOR | |
| SCHEMBL1790427 | 0.78 | ALDH1A1 (0.36) | IGF1RALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4457341 | 0.69 | SLC5A7 (0.44) | IGF1RKDM4ESMN1; SMN2 | |
| SCHEMBL1791389 | 0.68 | IGF1R (0.66) | IGF1RABL1BCRBMPR1BPLK4 | |
| SCHEMBL4455656 | 0.68 | IGF1R (0.42) | IGF1RABL1BCRBMPR1BPLK4 | |
| SCHEMBL4463976 | 0.68 | IGF1R (0.45) | IGF1R | |
| SCHEMBL4469774 | 0.67 | NUDT1 (0.49) | PIK3CAKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4458392 | 0.64 | DHFR (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |