Sugi Predict

Sugi Predict / Compounds / SCHEMBL4472039

SCHEMBL4472039

SCHEMBL4472039

Clc1ccc(C(Cl)(Cl)c2ccc(Cl)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 4/20 0.57
▸ MAPK1 P28482 2/20 0.57
▸ HIF1A Q16665 2/20 0.57
▸ LMNA P02545 2/20 0.53
▸ CYP2A6 P11509 1/20 0.53
▸ MEN1 O00255 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ CYP19A1 P11511 9/20 0.46
▸ TP53 P04637 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ TDP1 Q9NUW8 1/20 0.43
▸ MIF P14174 1/20 0.41
▸ IDO1 P14902 1/20 0.40
▸ POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7646185 0.89 TSHR (0.50) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL11867644 0.87 TSHR (0.46) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL11856617 0.87 POLB (0.53) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL6206704 0.87 CES2 (0.46) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL4476738 0.87 CYP19A1 (0.50) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL4456983 0.87 CES2 (0.46) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL9065534 0.84 TSHR (0.44) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL11867927 0.83 TSHR (0.60) TSHRMAPK1HIF1ALMNACYP2A6
SCHEMBL11867246 0.81 CYP19A1 (0.49) TSHRMAPK1HIF1AMEN1KMT2A
SCHEMBL11877834 0.81 MAOA (0.55) TSHRMAPK1HIF1ALMNACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001049642-A1 METHOD FOR PRODUCING DIARYLKETONES AND ACID HALIDES TESSENDERLO CHEMIE N.V. (BE) 2001-07-12 — — WO claimed
EP-3079098-B1 METHOD AND SYSTEM FOR GEO-DEMOGRAPHIC CLASSIFICATION OF A GEOGRAPHICAL REGION TATA CONSULTANCY SERVICES LTD (IN) 2023-11-29 — — EP disclosed
US-20210292264-A1 Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-09-23 — — US disclosed
US-11008273-B2 Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2021-05-18 — — US disclosed
US-20200262776-A1 New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2020-08-20 — — US disclosed
WO-2020164291-A1 NEW PROCESS FOR MANUFACTURE OF FLUORINATED BENZENES AND FLUORINATED BENZOPHENONES, AND DERIVATIVES THEREOF FUJIAN YONGJING TECHNOLOGY CO., LTD (CN) 2020-08-20 — — WO disclosed
US-20200262775-A1 Process for Friedel-Crafts Reaction, and Catalyst Therefore FUJIAN YONGJING TECHNOLOGY CO., LTD. (CN) 2020-08-20 — — US disclosed
US-7576088-B2 Benzodioxole derivatives HOFFMAN-LA ROCHE INC. (US) 2009-08-18 — — US disclosed
EP-1532132-B1 NOVEL BENZODIOXOLES HOFFMANN LA ROCHE (CH) 2008-03-19 — — EP disclosed
US-20050143373-A1 Benzodioxole derivatives ALANINE ALEXANDER (FR) 2005-06-30 — — US disclosed
US-6900227-B2 Benzodioxole derivatives HOFFMANN-LA ROCHE INC. (US) 2005-05-31 — — US disclosed
EP-1532132-A1 NOVEL BENZODIOXOLES F.HOFFMANN-LA ROCHE AG (CH) 2005-05-25 — — EP disclosed
US-20040142922-A1 Benzodioxole derivatives HOFFMANN-LA ROCHE INC. 2004-07-22 — — US disclosed
WO-2004013120-A1 NOVEL BENZODIOXOLES F. HOFFMANN-LA ROCHE AG (CH) 2004-02-12 — — WO disclosed
WO-2002042246-A1 METHOD FOR THE PREPARATION OF DICHLORODIARYLMETHANES TESSENDERLO CHEMIE N.V. (BE) 2002-05-30 — — WO disclosed
EP-0474164-B1 Process for producing p-halogenobenzophenone derivatives KUREHA CHEMICAL IND CO LTD (JP) 1995-02-01 — — EP disclosed
US-5113020-A Nonpolluting, solid catalyst, reaction of trichlorotoluene and chlorobenzene KUREHA KAGAKU KOGYO K.K. (JP) 1992-05-12 — — US disclosed
EP-0474164-A1 Process for producing p-halogenobenzophenone derivatives KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1992-03-11 — — EP disclosed
US-3985766-A ANTIMYCOTICS BAYER AKTIENGESELLSCHAFT (DT) 1976-10-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11008273-B2 Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof PFAS, PFKFB4, PFKFB2 TSHR 4577/4885MAPK1 1865/4885HIF1A 1452/4885
US-20050143373-A1 Benzodioxole derivatives CNR2, CNR1, GPR119 TSHR 1029/4885MAPK1 1793/4885HIF1A 853/4885
US-20200262776-A1 New Process for the Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof PFAS, PFKFB4, PFKFB1 TSHR 4557/4885MAPK1 1831/4885HIF1A 1652/4885
US-20210292264-A1 Process for Manufacture of Fluorinated Benzenes and Fluorinated Benzophenones, and Derivatives Thereof PFAS, PFKFB4, PFKFB2 TSHR 4621/4885MAPK1 1943/4885HIF1A 1809/4885
US-20200262775-A1 Process for Friedel-Crafts Reaction, and Catalyst Therefore HNF4A, TFEB, HACL2 TSHR 2377/4885MAPK1 4211/4885HIF1A 654/4885
US-20040142922-A1 Benzodioxole derivatives CNR1, CNR2, GPR119 TSHR 1171/4885MAPK1 789/4885HIF1A 603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.