Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504906 | 0.89 | MEN1 (0.45) | OPRM1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4494581 | 0.85 | ESR1 (0.38) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4559834 | 0.85 | PPARG (0.41) | MEN1KMT2AALDH1A1MMESMN1; SMN2 | |
| SCHEMBL4485668 | 0.79 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL4490045 | 0.77 | PPARG (0.42) | MEN1KMT2AALDH1A1SMN1; SMN2MMP1 | |
| SCHEMBL4504872 | 0.75 | LDHA (0.38) | MEN1KMT2AMMEL3MBTL1 | |
| SCHEMBL4491747 | 0.74 | MEN1 (0.40) | TDP1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4477469 | 0.74 | PDE1C (0.47) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4492334 | 0.73 | TAAR1 (0.36) | MEN1KMT2AAKR1C3 | |
| SCHEMBL4481909 | 0.73 | KDM4E (0.40) | TDP1MEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |