Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485206 | 0.89 | ALDH1A1 (0.32) | KDM4EPOLBALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4494581 | 0.83 | ESR1 (0.38) | ALDH1A1SMN1; SMN2LDHALDHBNPC1 | |
| SCHEMBL4504872 | 0.79 | LDHA (0.38) | L3MBTL1LDHALDHBNPC1RAB9A | |
| SCHEMBL4485668 | 0.78 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL4492334 | 0.77 | TAAR1 (0.36) | LMNAHPGDLDHALDHBNPC1 | |
| SCHEMBL4490045 | 0.77 | PPARG (0.42) | KDM4EALDH1A1SMN1; SMN2HPGDLDHA | |
| SCHEMBL4482572 | 0.77 | PPARG (0.41) | KDM4EALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL4559834 | 0.77 | PPARG (0.41) | POLBLMNAALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4504906 | 0.75 | MEN1 (0.45) | POLBALDH1A1SMN1; SMN2L3MBTL1NPC1 | |
| SCHEMBL4477477 | 0.73 | TDP1 (0.42) | ALDH1A1SMN1; SMN2L3MBTL1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |