Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | LDHB | P07195 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494581 | 0.90 | ESR1 (0.38) | LDHALDHBALOX5RAB9AALDH1A1 | |
| SCHEMBL4477477 | 0.85 | TDP1 (0.42) | MMEALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4485668 | 0.83 | ALDH1A1 (0.39) | ALDH1A1 | |
| SCHEMBL4504872 | 0.81 | LDHA (0.38) | PPARGPPARALDHALDHBMME | |
| SCHEMBL4490045 | 0.81 | PPARG (0.42) | PPARGPPARALDHARAB9AALDH1A1 | |
| SCHEMBL4504906 | 0.79 | MEN1 (0.45) | POLBRAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL4485206 | 0.79 | ALDH1A1 (0.32) | LDHALDHBPOLBRAB9AALDH1A1 | |
| SCHEMBL4492334 | 0.77 | TAAR1 (0.36) | LDHALDHBALOX5RAB9AKMT2A | |
| SCHEMBL4481909 | 0.77 | KDM4E (0.40) | LDHALDHBPOLBRAB9AALDH1A1 | |
| SCHEMBL4491011 | 0.75 | SMN1; SMN2 (0.44) | LDHALDHBRAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |