Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977960 | 0.88 | RAB9A (0.63) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29559580 | 0.87 | ALDH1A1 (0.59) | MAPTKAT2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9365470 | 0.87 | MAPT (0.54) | MAPTKAT2BRECQLNPC1RAB9A | |
| SCHEMBL22587352 | 0.87 | ALDH1A1 (0.59) | MAPTKAT2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18256280 | 0.84 | RAB9A (0.53) | MAPTKAT2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5705175 | 0.84 | L3MBTL1 (0.67) | MAPTSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL22535975 | 0.83 | CYP3A4 (0.55) | MAPTKAT2BSMN1; SMN2KMT2ACYP3A4 | |
| SCHEMBL18256216 | 0.82 | NPC1 (0.51) | MAPTKAT2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9836378 | 0.81 | CYP3A4 (0.53) | MAPTKAT2BNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6170373 | 0.81 | KMT2A (0.64) | MAPTRECQLNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618997-B2 | Diaminofluorescein derivatives | SEKISUI MEDICAL CO., LTD. (JP) | 2009-11-17 | — | — | US | disclosed |
| US-20070117211-A1 | Diaminofluorescein derivatives | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
| US-20050130314-A1 | Diaminofluorescein derivatives | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| US-6833386-B2 | Are useful as agents for measurement of nitrogen monoxide. | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2004-12-21 | — | — | US | disclosed |
| US-20030207865-A1 | Substituted 2-arylimino heterocycles and compositions containing them for use as progesterone receptor binding agents | DIXON BRIAN R (US) | 2003-11-06 | — | — | US | disclosed |
| US-20030171600-A1 | Diaminofluorescein derivatives | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2003-09-11 | — | — | US | disclosed |
| US-6569892-B2 | Useful as agent for measurement of nitrogen monoxide, also for measuring intracellular nitrogen monoxide concentration of an individual | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2003-05-27 | — | — | US | disclosed |
| US-20020137225-A1 | Diaminofluorescein derivatives | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2002-09-26 | — | — | US | disclosed |
| US-6441197-B1 | 4-AMINO-5-(N-METHYLAMINO)-2',7'-DIFLUORO-3',6'-DIHYDROXY-SPIRO (ISOBENZOFURAN-1,9'-XANTHEN)-3-ONE; DIRECT, ACCURATE, HIGHLY SENSITIVE INTRACELLULAR FLUORESCENT MEASUREMENT OF NITROGEN MONOXIDE; NONDAMAGING TO TISSUES AND CELLS; LIGHT STABLE | DAIICHI PURE CHEMICALS CO., LTD. (JP) | 2002-08-27 | — | — | US | disclosed |
| US-6353006-B1 | TREATMENT OF BONE DISORDERS, OSTEOPOROSIS AND HEALING AGENT | BAYER CORPORATION | 2002-03-05 | — | — | US | disclosed |
| EP-1144396-A2 | SUBSTITUTED 2-ARYLIMINO HETEROCYCLES AND COMPOSITIONS CONTAINING THEM, FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS | Bayer Corporation (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000042031-A2 | SUBSTITUTED 2-ARYLIMINO HETEROCYCLES AND COMPOSITIONS CONTAINING THEM, FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS | BAYER CORPORATION (US) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130314-A1 | Diaminofluorescein derivatives | NOS2, NOS3, NOS1 | MAPT 4325/4885KAT2B 1085/4885RECQL 481/4885 |
| US-20020137225-A1 | Diaminofluorescein derivatives | PRMT1, ARGLU1, DAO | MAPT 4354/4885KAT2B 1385/4885RECQL 567/4885 |
| US-20030207865-A1 | Substituted 2-arylimino heterocycles and compositions containing them for use as progesterone receptor binding agents | PGR, PGRMC2, PGRMC1 | MAPT 4372/4885KAT2B 2864/4885RECQL 4132/4885 |
| US-20070117211-A1 | Diaminofluorescein derivatives | NOS2, NOS3, NOS1 | MAPT 4325/4885KAT2B 1085/4885RECQL 481/4885 |
| US-20030171600-A1 | Diaminofluorescein derivatives | PRMT1, ARGLU1, DAO | MAPT 4354/4885KAT2B 1385/4885RECQL 567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.