Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 7/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.38 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.38 |
| ▸ | SLC37A4 | O43826 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4504869 | 0.85 | ALDH1A1 (0.42) | KMT2ATDP2NSD2PLCG1PAX8 | |
| SCHEMBL4488093 | 0.85 | VDR (0.40) | KMT2ATDP2NSD2PLCG1PAX8 | |
| SCHEMBL4492957 | 0.84 | GRIA2 (0.42) | PLA2G2AGFERKMT2AKDM4EALDH1A1 | |
| SCHEMBL4490040 | 0.82 | GFER (0.47) | PLA2G2AGFERKDM4EALDH1A1HPGD | |
| SCHEMBL4494579 | 0.82 | ALDH1A1 (0.43) | KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL4493743 | 0.81 | GRIA2 (0.39) | KMT2ATDP2NSD2PLCG1PAX8 | |
| SCHEMBL4485732 | 0.80 | KMT2A (0.47) | PLA2G2AKMT2APLA2G1B | |
| SCHEMBL4492331 | 0.77 | LMNA (0.42) | KMT2AALDH1A1 | |
| SCHEMBL4485664 | 0.77 | KDM4E (0.40) | KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4559832 | 0.76 | TP53 (0.46) | KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |