Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494579 | 0.90 | ALDH1A1 (0.43) | MAPTALDH1A1HPGDHTTNPSR1 | |
| SCHEMBL4485732 | 0.88 | KMT2A (0.47) | EDNRBPLA2G2AFEN1PLA2G1B | |
| SCHEMBL4485664 | 0.84 | KDM4E (0.40) | MAPTALDH1A1NPSR1SMN1; SMN2KDM4E | |
| SCHEMBL4492336 | 0.83 | AR (0.47) | ALDH1A1HPGDNPSR1SMN1; SMN2FEN1 | |
| SCHEMBL4504902 | 0.83 | AR (0.57) | PLA2G2AMAPTALDH1A1HTTKDM4E | |
| SCHEMBL4482567 | 0.82 | PLA2G2A (0.43) | GFERPLA2G2AALDH1A1HPGDKDM4E | |
| SCHEMBL4559832 | 0.80 | TP53 (0.46) | MAPTTP53ALDH1A1HPGDHTT | |
| SCHEMBL4490747 | 0.80 | PGR (0.43) | PLA2G2AMAPTALDH1A1HPGDHTT | |
| SCHEMBL4488093 | 0.78 | VDR (0.40) | MAPTALDH1A1HTTNPSR1SMN1; SMN2 | |
| SCHEMBL4504869 | 0.78 | ALDH1A1 (0.42) | MAPTALDH1A1HTTNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |