Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485664 | 0.92 | KDM4E (0.40) | ALDH1A1POLBKDM4ELMNANPSR1 | |
| SCHEMBL4490040 | 0.90 | GFER (0.47) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL4490747 | 0.90 | PGR (0.43) | ALDH1A1KDM4EHPGDLMNASMN1; SMN2 | |
| SCHEMBL4559832 | 0.90 | TP53 (0.46) | ALDH1A1HPGDLMNANPSR1SMN1; SMN2 | |
| SCHEMBL4492336 | 0.89 | AR (0.47) | ALDH1A1POLBKDM4EHPGDLMNA | |
| SCHEMBL4504902 | 0.88 | AR (0.57) | ALDH1A1POLBKDM4ELMNAMEN1 | |
| SCHEMBL4485732 | 0.87 | KMT2A (0.47) | POLBKMT2A | |
| SCHEMBL4484664 | 0.86 | CFTR (0.45) | ALDH1A1LMNAAR | |
| SCHEMBL4488093 | 0.85 | VDR (0.40) | ALDH1A1POLBLMNANPSR1SMN1; SMN2 | |
| SCHEMBL4504869 | 0.85 | ALDH1A1 (0.42) | ALDH1A1POLBLMNANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |