Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488093 | 0.84 | VDR (0.40) | PPARGALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4504869 | 0.84 | ALDH1A1 (0.42) | PPARGALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4492336 | 0.83 | AR (0.47) | GRIA2GRIA4ALDH1A1MEN1KMT2A | |
| SCHEMBL4482567 | 0.81 | PLA2G2A (0.43) | ALDH1A1KMT2ATDP2NSD2PLCG1 | |
| SCHEMBL4494579 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL4484664 | 0.80 | CFTR (0.45) | GRIA2GRIA4ALDH1A1LMNA | |
| SCHEMBL4492331 | 0.77 | LMNA (0.42) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL4485664 | 0.76 | KDM4E (0.40) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL4490747 | 0.75 | PGR (0.43) | PPARGALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4485204 | 0.75 | ALDH1A1 (0.42) | ALDH1A1MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504429-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | claimed |