SCHEMBL450618

SCHEMBL450618

[CH2]c1ccccc1NC(=O)CCNC(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.46
CA2 P00918 3/20 0.46
MALT1 Q9UDY8 1/20 0.43
IDO1 P14902 1/20 0.43
GAA P10253 1/20 0.43
POLB P06746 2/20 0.42
LMNA P02545 1/20 0.42
KDM4E B2RXH2 3/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
SIGMAR1 Q99720 1/20 0.42
BCHE P06276 1/20 0.41
NAMPT P43490 1/20 0.41
CYP3A4 P08684 1/20 0.41
TSHR P16473 1/20 0.40
DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13233342 0.85 CA1 (0.49) CA1CA2MALT1IDO1GAA
SCHEMBL8290128 0.84 HDAC3 (0.55) CA1CA2
SCHEMBL13900420 0.84 CA1 (0.48) CA1CA2MALT1IDO1POLB
SCHEMBL8692644 0.84 POLB (0.55) CA1CA2GAAPOLBKDM4E
SCHEMBL12472110 0.82 CA1 (0.48) CA1CA2MALT1IDO1GAA
SCHEMBL9524622 0.82 CYP1A2 (0.59) CA1CA2POLBLMNAKDM4E
SCHEMBL13936405 0.82 CA1 (0.49) CA1CA2GAAPOLBKDM4E
SCHEMBL1524995 0.81 LMNA (0.48) CA1IDO1GAAPOLBLMNA
SCHEMBL6274441 0.81 CA1 (0.58) CA1CA2IDO1L3MBTL1SIGMAR1
SCHEMBL5583416 0.80 ALDH1A1 (0.56) CA1CA2IDO1POLBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160263142-A1 USE OF A3 ADENOSINE RECEPTOR AGONIST IN OSTEOARTHRITIS TREATMENT CAN-FITE BIOPHARMA LTD. (IL) 2016-09-15 US claimed
US-9387220-B2 Method for inducing hepatocyte proliferation and uses thereof CAN-FITE BIOPHARMA LTD. (IL) 2016-07-12 US claimed
US-20140364388-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF CAN-FITE BIOPHARMA LTD. (IL) 2014-12-11 US claimed
US-8846635-B2 Method for inducing hepatocyte proliferation and uses thereof CAN-FITE BIOPHARMA LTD. (IL) 2014-09-30 US claimed
EP-2227234-B1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF CAN FITE BIOPHARMA LTD (IL) 2014-05-07 EP claimed
US-20130109645-A1 ADENOSINE RECEPTOR AGONISTS FOR THE TREATMENT AND PREVENTION OF VASCULAR OR JOINT CAPSULE CALCIFICATION DISORDERS The united States of America,as represented by Secretary,Dept.,of Health and Human Services (US) 2013-05-02 US claimed
US-20100249053-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF CAN-FITE BIOPHARMA LTD. (IL) 2010-09-30 US claimed
EP-2227234-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF Can-Fite Biopharma Ltd. (IL) 2010-09-15 EP claimed
WO-2009050707-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF CAN-FITE BIOPHARMA LTD. (IL) 2009-04-23 WO claimed
US-7465715-B2 Method for treatment of multiple sclerosis CAN-FITE BIOPHARMA, LTD. (IL) 2008-12-16 US claimed
WO-2006011130-A1 ADENOSINE A3 RECEPTOR AGONISTS FOR THE TREATMENT OF DRY EYE DISORDERS INCLUDING SJOGREN’S SYNDROME CAN-FITE BIOPHARMA LTD. (IL) 2006-02-02 WO claimed
WO-2005063246-A1 METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS CAN-FITE BIOPHARMA LTD. (IL) 2005-07-14 WO claimed
EP-1383515-B1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS CAN FITE BIOPHARMA LTD (IL) 2004-12-15 EP claimed
US-20040204481-A1 Activation of natural killer cells by adenosine A3 receptor agonists CAN-FITE BIOPHARMA LTD. (IL) 2004-10-14 US claimed
EP-1383515-A1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS Can-Fite Biopharma Ltd. (IL) 2004-01-28 EP claimed
JP-2003514771-A 2003-04-22 JP claimed
EP-1261322-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ADENOSINE RECEPTOR AGONIST OR ANTAGONIST Can-Fite Biopharma Ltd. (IL) 2002-12-04 EP claimed
WO-2002083152-A1 ACTIVATION OF NATURAL KILLER CELLS BY ADENOSINE A3 RECEPTOR AGONISTS CAN-FITE BIOPHARMA LTD. (IL) 2002-10-24 WO claimed
WO-2001019360-A2 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ADENOSINE RECEPTOR AGONIST OR ANTAGONIST CAN-FITE BIOPHARMA LTD. (IL) 2001-03-22 WO claimed
US-5688774-A ANTIINFLAMMATORY AGENTS, HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1997-11-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140364388-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF HGF, HCAR3, HNF4A CA1 2046/4885CA2 2577/4885MALT1 4481/4885
US-20160263142-A1 USE OF A3 ADENOSINE RECEPTOR AGONIST IN OSTEOARTHRITIS TREATMENT ADORA3, ADORA2A, ADORA1 CA1 1819/4885CA2 2826/4885MALT1 4814/4885
US-20040204481-A1 Activation of natural killer cells by adenosine A3 receptor agonists ADORA3, ADORA2A, ADORA1 CA1 4543/4885CA2 3752/4885MALT1 1344/4885
US-20130109645-A1 ADENOSINE RECEPTOR AGONISTS FOR THE TREATMENT AND PREVENTION OF VASCULAR OR JOINT CAPSULE CALCIFICATION DISORDERS NT5E, NT5C2, NT5C3B CA1 1948/4885CA2 1174/4885MALT1 3260/4885
US-20100249053-A1 METHOD FOR INDUCING HEPATOCYTE PROLIFERATION AND USES THEREOF HGF, HCAR3, HNF4A CA1 2046/4885CA2 2577/4885MALT1 4481/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.