Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | MGAM | O43451 | 3/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.37 |
| ▸ | SI | P14410 | 3/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2032632 | 0.79 | GAA (0.41) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL16600359 | 0.72 | GAA (0.39) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL15973447 | 0.68 | MGAM (0.47) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL2050918 | 0.67 | SLC9A1 (0.48) | NPC1RAB9ASMN1; SMN2HPGDKDM4E | |
| SCHEMBL4054573 | 0.66 | KCNMA1 (0.61) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL16211069 | 0.66 | ALDH1A1 (0.46) | GAAKMT2ANPC1RAB9AMCL1 | |
| Methyl Alcohol SCHEMBL28226904 | 0.65 | GAA (0.67) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL4737248 | 0.65 | ALDH1A1 (0.41) | GAAMGAMAMY1ASIMGAM2 | |
| SCHEMBL170673 | 0.64 | GAA (0.71) | GAAMGAMAMY1ASIMGAM2 | |
| Ammonia Solution, Strong SCHEMBL3505685 | 0.63 | GAA (0.69) | GAAMGAMAMY1ASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9238647-B2 | P2X3 receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | MERCK SHARP & DOHME LLC | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064181-A1 | P2X3 Receptor Antagonists for Treatment of Pain | P2RX3, P2RX1, P2RX2 | GAA 4548/4885MGAM 4411/4885AMY1A 4475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.