SCHEMBL453066

SCHEMBL453066

CCCCCNCCc1c[nH]c2ccc(O)cc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 8/20 0.67
KDM4E B2RXH2 3/20 0.67
MPO P05164 3/20 0.67
CYP2D6 P10635 2/20 0.67
HTR2C P28335 2/20 0.67
MEN1 O00255 1/20 0.67
KMT2A Q03164 1/20 0.67
HTR1D P28221 3/20 0.63
HTR1A P08908 1/20 0.63
HTR1B P28222 1/20 0.63
ALDH1A1 P00352 2/20 0.61
NPSR1 Q6W5P4 2/20 0.61
SPR P35270 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
MAPT P10636 1/20 0.61
IDO1 P14902 1/20 0.61
HPGD P15428 1/20 0.61
BLM P54132 1/20 0.61
NOTUM Q6P988 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14907374 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL25076883 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL25076703 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL23633206 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL23630275 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL25076884 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL23633204 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL25076891 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL23630278 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C
SCHEMBL27514454 0.99 TRPV1 (0.69) TRPV1KDM4EMPOCYP2D6HTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0983060-A4 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP (US) 2002-04-24 EP claimed
US-20020039594-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX THERAPEUTICS, INC. 2002-04-04 US claimed
EP-0983060-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 2000-03-08 EP claimed
WO-1998051282-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 1998-11-19 WO claimed
WO-2024008341-A1 SEROTONIN ANALOGUES FOR USE IN TREATING METALLOPTOSIS-ASSOCIATED DISORDERS INSTITUT CURIE (FR) 2024-01-11 WO disclosed
WO-2023021112-A1 NOVEL SEROTONIN DERIVATIVES AND THEIR USES FOR TREATING IRON-ASSOCIATED DISORDERS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 2023-02-23 WO disclosed
US-20120021036-A1 COMPOSITE NANOSTRUCTURES AND METHODS FOR MAKING AND USING THEM THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2012-01-26 US disclosed
US-20120021914-A1 Cyclodextrin-containing suspension concentrates, method for producing the same and their use BASF SE (DE) 2012-01-26 US disclosed
WO-2010083337-A2 COMPOSITE NANOSTRUCTURES AND METHODS FOR MAKING AND USING THEM THE REGENTS OF THE UNIVERSITY OF CALIFORINIA (US) 2010-07-22 WO disclosed
US-20080319375-A1 Materials, Methods, and Systems for Cavitation-mediated Ultrasonic Drug Delivery in vivo BIOVALUATION & ANALYSIS, INC. 2008-12-25 US disclosed
WO-2008157422-A1 MATERIALS, METHODS, AND SYSTEMS FOR CAVITATION-MEDIATED ULTRASONIC DRUG DELIVERY HARDY CHARLES THOMAS (US) 2008-12-24 WO disclosed
US-20080312581-A1 Peptosomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo BIOVALUATION & ANALYSIS, INC. 2008-12-18 US disclosed
EP-0983060-A4 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP (US) 2002-04-24 EP disclosed
EP-0981333-A4 NOVEL ACOUSTICALLY ACTIVE DRUG DELIVERY SYSTEMS IMARX PHARMACEUTICAL CORP (US) 2002-04-24 EP disclosed
US-20020039594-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX THERAPEUTICS, INC. 2002-04-04 US disclosed
US-20010018072-A1 Solid matrix therapeutic compositions IMARX THERAPEUTICS, INC. 2001-08-30 US disclosed
EP-0983060-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 2000-03-08 EP disclosed
EP-0981333-A1 NOVEL ACOUSTICALLY ACTIVE DRUG DELIVERY SYSTEMS IMARX PHARMACEUTICAL CORP. (US) 2000-03-01 EP disclosed
WO-1998051282-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME IMARX PHARMACEUTICAL CORP. (US) 1998-11-19 WO disclosed
WO-1998051284-A1 NOVEL ACOUSTICALLY ACTIVE DRUG DELIVERY SYSTEMS IMARX PHARMACEUTICAL CORP. (US) 1998-11-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080312581-A1 Peptosomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo MYOC, PITRM1, VIP TRPV1 873/4885KDM4E 4820/4885MPO 4204/4885
US-20120021914-A1 Cyclodextrin-containing suspension concentrates, method for producing the same and their use GYS2, DCXR, ADH1C TRPV1 4389/4885KDM4E 2863/4885MPO 2795/4885
US-20020039594-A1 SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME EXOSC9, EXOSC5, EXOSC4 TRPV1 1408/4885KDM4E 1279/4885MPO 1354/4885
US-20010018072-A1 Solid matrix therapeutic compositions MMP7, MMP1, MMP17 TRPV1 3939/4885KDM4E 3658/4885MPO 396/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.