Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 8/20 | 0.53 |
| ▸ | MMP3 | P08254 | 7/20 | 0.53 |
| ▸ | MMP7 | P09237 | 6/20 | 0.53 |
| ▸ | MMP13 | P45452 | 4/20 | 0.53 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 6/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | MMP8 | P22894 | 5/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542205 | 0.97 | RAB9A (0.52) | MMP1MMP3MMP7MMP13BDKRB1 | |
| SCHEMBL4540868 | 0.89 | BDKRB1 (0.49) | BDKRB1RAB9APAX8 | |
| SCHEMBL4537833 | 0.87 | RAB9A (0.48) | NPC1RAB9A | |
| SCHEMBL4541294 | 0.87 | PSEN1 (0.56) | BDKRB1PAX8 | |
| SCHEMBL4537242 | 0.87 | NPC1 (0.53) | BDKRB1NPC1RAB9A | |
| SCHEMBL4537185 | 0.87 | RAB9A (0.56) | MMP1MMP3MMP7MMP13NPC1 | |
| SCHEMBL4536688 | 0.86 | FKBP1A (0.51) | BDKRB1NPC1RAB9ACNR2HCRTR1 | |
| SCHEMBL4541024 | 0.86 | RAB9A (0.48) | BDKRB1RAB9APAX8 | |
| SCHEMBL4535169 | 0.86 | HTR7 (0.54) | BDKRB1RAB9ACNR2HCRTR1HCRTR2 | |
| SCHEMBL4539776 | 0.85 | BRD4 (0.53) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |