Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 10/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 11/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535721 | 0.85 | EPHX2 (0.63) | EPHX1EPHX2 | |
| SCHEMBL4537349 | 0.80 | EPHX2 (0.69) | EPHX1EPHX2 | |
| SCHEMBL4539949 | 0.79 | EPHX1 (0.55) | EPHX1EPHX2CACNA1HLMNA | |
| SCHEMBL4535944 | 0.76 | EPHX1 (0.52) | EPHX1EPHX2LMNA | |
| SCHEMBL4540431 | 0.76 | NPC1 (0.55) | EPHX1EPHX2LMNA | |
| SCHEMBL8060150 | 0.75 | EPHX1 (0.56) | EPHX1EPHX2CACNA1HFAAH | |
| SCHEMBL4539129 | 0.74 | EPHX2 (0.52) | EPHX1EPHX2CACNA1HLMNA | |
| SCHEMBL4539274 | 0.74 | CYP3A4 (0.51) | EPHX1EPHX2LMNA | |
| SCHEMBL4536776 | 0.74 | LMNA (0.62) | EPHX1EPHX2LMNA | |
| SCHEMBL4540032 | 0.74 | PKM (0.51) | EPHX1EPHX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |