SCHEMBL453878

SCHEMBL453878

Cc1ccc(NCc2ccco2)cc1O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.68
MAPT P10636 7/20 0.68
KDM4E B2RXH2 5/20 0.68
GAA P10253 4/20 0.68
TDP1 Q9NUW8 1/20 0.68
SHMT2 P34897 1/20 0.50
HPGD P15428 5/20 0.48
ALOX15 P16050 2/20 0.48
HSD17B10 Q99714 2/20 0.48
TP53 P04637 1/20 0.48
GLA P06280 1/20 0.48
CASP1 P29466 1/20 0.48
CASP7 P55210 1/20 0.48
TUBB4A P04350 1/20 0.47
TUBB P07437 1/20 0.47
TUBA3C P0DPH7 1/20 0.47
TUBA1B P68363 1/20 0.47
TUBA4A P68366 1/20 0.47
TUBB4B P68371 1/20 0.47
TUBB3 Q13509 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4799612 0.79 ALDH1A1 (0.51) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL11792458 0.77 SMN1; SMN2 (0.59) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL5713786 0.75 GFER (0.46) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL5713517 0.74 TUBB4A (0.58) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL5713616 0.74 ARG1 (0.70) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL5713631 0.73 MAPT (0.82) ALDH1A1MAPTKDM4EGAAHPGD
SCHEMBL13605317 0.73 ALDH1A1 (0.54) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL29286764 0.73 MAPT (0.55) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL10873813 0.73 GAA (0.52) ALDH1A1MAPTKDM4EGAATDP1
SCHEMBL5713554 0.73 L3MBTL1 (0.62) ALDH1A1MAPTKDM4EGAATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12133906-B2 Delivery particle THE PROCTER & GAMBLE COMPANY (US) 2024-11-05 US disclosed
US-20220409497-A1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2022-12-29 US disclosed
EP-3733827-A1 DELIVERY PARTICLES The Procter & Gamble Company (US) 2020-11-04 EP disclosed
EP-2563508-B1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2019-07-10 EP disclosed
EP-1642563-B1 Method of rapid hair dyeing NOXELL CORP (US) 2019-06-26 EP disclosed
US-20190142714-A1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2019-05-16 US disclosed
EP-1484048-B1 Hair colouring compositions NOXELL CORP (US) 2019-01-02 EP disclosed
US-20180360706-A1 Delivery Particles PROCTER & GAMBLE (US) 2018-12-20 US disclosed
EP-2308564-B1 Thickened hair colourant and bleaching compositions NOXELL CORP (US) 2018-12-19 EP disclosed
US-9993793-B2 Delivery particles THE PROCTER & GAMBLE COMPANY (US) 2018-06-12 US disclosed
WO-2005074875-A2 KERATIN DYEING COMPOUNDS, KERATIN DYEING COMPOSITIONS CONTAINING THEM, AND USE THEREOF THE PROCTER & GAMBLE COMPANY (US) 2005-08-18 WO disclosed
CN-1196464-C Novel couplers for oxidative hair dyeing P & G CLAROR INC (US) 2005-04-13 CN disclosed
WO-2004108102-A1 HAIR COLOURING COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2004-12-16 WO disclosed
EP-1484048-A1 Hair colouring compositions The Procter & Gamble Company (US) 2004-12-08 EP disclosed
US-20040237218-A1 Hair colouring compositions WELLA OPERATIONS US, LLC 2004-12-02 US disclosed
US-6540793-B1 Coupler for use in oxidative hair dyeing CLAIROL INCORPORATED 2003-04-01 US disclosed
CN-1396819-A Novel couplers for oxidative hair dyeing P & G CLAROR INC (US) 2003-02-12 CN disclosed
EP-1251822-A1 NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING Clairol Incorporated (US) 2002-10-30 EP disclosed
WO-2001056538-A1 NOVEL COUPLER FOR USE IN OXIDATIVE HAIR DYEING P&G-CLAIROL, INC. (US) 2001-08-09 WO disclosed
US-6200353-B1 Coupler for use in oxidative hair dyeing BRISTOL MYERS SQUIBB COMPANY 2001-03-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220409497-A1 DELIVERY PARTICLE LIPA, CHMP4B, SLC46A1 ALDH1A1 1476/4885MAPT 2207/4885KDM4E 4662/4885
US-20180360706-A1 Delivery Particles LIPA, CHMP4B, ABCB4 ALDH1A1 1320/4885MAPT 2431/4885KDM4E 4706/4885
US-12133906-B2 Delivery particle LIPA, CHMP4B, SLC46A1 ALDH1A1 1476/4885MAPT 2207/4885KDM4E 4662/4885
US-20190142714-A1 DELIVERY PARTICLE LIPA, CHMP4B, SLC46A1 ALDH1A1 1476/4885MAPT 2207/4885KDM4E 4662/4885
US-20040237218-A1 Hair colouring compositions COXFA4L2, CYBA, MT-CO3 ALDH1A1 436/4885MAPT 1639/4885KDM4E 1189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.