Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28814497 | 0.79 | MAPK14 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9ACLK4 | |
| SCHEMBL2918159 | 0.79 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL453506 | 0.76 | KDM4E (0.48) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL22353121 | 0.75 | RAB9A (0.49) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL15348468 | 0.74 | HPGD (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL20605668 | 0.74 | ALOX15 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL170101 | 0.74 | ALOX15 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL2387037 | 0.74 | AKT2 (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL2048675 | 0.74 | ALOX15 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA | |
| SCHEMBL8776626 | 0.74 | ALOX15 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137483-A1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2025-06-26 | — | — | WO | disclosed |
| US-10738056-B2 | Pyrazolopyrimidinone compounds and uses thereof | ADURO BIOTECH INC. (US) | 2020-08-11 | — | — | US | disclosed |
| EP-3681888-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | Aduro Biotech, Inc. (US) | 2020-07-22 | — | — | EP | disclosed |
| CN-111212839-A | Pyrazolopyrimidinone compounds and uses thereof | 艾杜罗生物科技公司 | 2020-05-29 | — | — | CN | disclosed |
| US-20190119285-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | CHINOOK THERAPEUTICS, INC. | 2019-04-25 | — | — | US | disclosed |
| WO-2019055750-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | Aduro Biotech, Inc. (US) | 2019-03-21 | — | — | WO | disclosed |
| US-20180369262-A1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | TETARD, INC. | 2018-12-27 | — | — | US | disclosed |
| CN-108026063-A | Pleocidin derivative as insecticide | 阿格里麦蒂斯有限责任公司 | 2018-05-11 | — | — | CN | disclosed |
| EP-2365747-B1 | METHODS FOR TREATING GASTROINTESTINAL DISEASES | CEMPRA PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2362727-B1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | CEMPRA PHARMACEUTICALS INC (US) | 2018-04-11 | — | — | EP | disclosed |
| WO-2010048601-A1 | BIODEFENSES USING TRIAZOLE-CONTAINING MACROLIDES | CEMPRA PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048599-A1 | METHODS FOR TREATING GASTROINTESTINAL DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048600-A1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | CEMPRA PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| US-6451820-B1 | Substituted 1-(4-aminophenly)triazoles and their use as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-09-17 | — | — | US | disclosed |
| WO-2001072740-A1 | SUBSTITUTED 1-(4-AMINOPHENYL) TRIAZOLES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2001-10-04 | — | — | WO | disclosed |
| US-4282008-A | METHANOL AND/OR ETHANOL; REACTION PRODUCT OF ISATOIC ANHYDRIDE, AMINOTRIAZOLE, POLY-PRIMARY AMINE; CORROSION RESISTANCE | TEXACO INC. (US) | 1981-08-04 | — | — | US | disclosed |
| EP-0001774-A1 | Derivatives of BPTI (basic pancreatic trypsin-inhibitor), process for their preparation and their use as medicines | BAYER AG (DE) | 1979-05-16 | — | — | EP | disclosed |
| EP-0001773-A1 | Derivatives of BPTI (basic pancreatic trypsin-inhibitor), process for their preparation and their use as medicines | BAYER AG (DE) | 1979-05-16 | — | — | EP | disclosed |
| US-4153687-A | Derivatives, having an inhibitory action against protease and an antiphlogistic action, of the trypsin-kallikrein inhibitor obtained from cattle organs (BPTI), their preparation and their use as medicaments | BAYER AKTIENGESELLSCHAFT (DE) | 1979-05-08 | — | — | US | disclosed |
| US-4060531-A | OPTICAL BRIGTENERS | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1977-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180369262-A1 | METHODS FOR TREATING RESISTANT DISEASES USING TRIAZOLE CONTAINING MACROLIDES | LIPA, PNLIP, LIPC | ALDH1A1 3064/4885KDM4E 4245/4885HPGD 808/4885 |
| US-10738056-B2 | Pyrazolopyrimidinone compounds and uses thereof | NLRP3, NLRP1, P2RX7 | ALDH1A1 1246/4885KDM4E 1922/4885HPGD 280/4885 |
| US-20190119285-A1 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF | NLRP3, NLRP1, P2RX7 | ALDH1A1 1246/4885KDM4E 1922/4885HPGD 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.