Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGB1 | P09429 | 1/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.56 |
| ▸ | CTH | P32929 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 13/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6900728 | 0.88 | CA5A (0.48) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL6969296 | 0.84 | HMGB1 (0.47) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL1644952 | 0.83 | CA5A (0.56) | ALDH1A1CA5ALMNACYP3A4CYP2C9 | |
| SCHEMBL28009479 | 0.82 | LMNA (0.52) | HMGB1CXCL12KDM4EALDH1A1HPGD | |
| SCHEMBL27733846 | 0.79 | KDM4E (0.47) | KDM4EAKR1C3AKR1C2CA5AKMT2A | |
| SCHEMBL10763288 | 0.78 | MMP2 (0.46) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL10421181 | 0.78 | KMT2A (0.51) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL9508765 | 0.78 | HMGB1 (0.54) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL122472 | 0.77 | HMGB1 (0.62) | HMGB1CXCL12CTHKDM4EALDH1A1 | |
| SCHEMBL13144722 | 0.77 | CA5A (0.50) | KDM4EALDH1A1HPGDHSD17B10CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885411-B1 | MEANS AND METHODS FOR ALTERING THE LIGNIN PATHWAY IN PLANTS | VIB VZW (BE) | 2018-12-05 | — | — | EP | disclosed |
| US-10006041-B2 | Means and methods for altering the lignin pathway in plants | VIB VZW (BE) | 2018-06-26 | — | — | US | disclosed |
| US-20150232872-A1 | MEANS AND METHODS FOR ALTERING THE LIGNIN PATHWAY IN PLANTS | UNIVERSITEIT GENT (BE) | 2015-08-20 | — | — | US | disclosed |
| EP-2885411-A1 | MEANS AND METHODS FOR ALTERING THE LIGNIN PATHWAY IN PLANTS | VIB vzw (BE) | 2015-06-24 | — | — | EP | disclosed |
| US-8790548-B2 | Carbonaceous materials | UNIVERSITY OF YORK (GB) | 2014-07-29 | — | — | US | disclosed |
| WO-2014027021-A1 | MEANS AND METHODS FOR ALTERING THE LIGNIN PATHWAY IN PLANTS | VIB VZW (BE) | 2014-02-20 | — | — | WO | disclosed |
| WO-2012032546-A2 | PROCESS FOR THE PREPARATION OF SALMETEROL AND ITS INTERMEDIATES | CADILA HEALTHCARE LIMITED (IN) | 2012-03-15 | — | — | WO | disclosed |
| US-7605163-B2 | Benzoyl-piperazine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-10-20 | — | — | US | disclosed |
| US-20090078913-A1 | CARBONACEOUS MATERIALS | STARBONS LIMITED (GB) | 2009-03-26 | — | — | US | disclosed |
| EP-2007675-A2 | CARBONACEOUS MATERIALS | University of York (GB) | 2008-12-31 | — | — | EP | disclosed |
| US-20050209241-A1 | Benzoyl-piperazine derivatives | HOFFMANN-LA ROCHE INC. | 2005-09-22 | — | — | US | disclosed |
| WO-2005014563-A1 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-17 | — | — | WO | disclosed |
| US-6649636-B1 | Cyclooxygenase inhibitors | PFIZER INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1104759-B1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | PFIZER PROD INC (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6534501-B2 | Allosteric inhibitors of pyruvate kinase | ALLOS THERAPEUTICS, INC. | 2003-03-18 | — | — | US | disclosed |
| US-20010046997-A1 | Allosteric inhibitors of pyruvate kinase | ALLOS THERAPEUTICS, INC. | 2001-11-29 | — | — | US | disclosed |
| EP-1104759-A1 | Heteroaryl phenyl pyrazole compounds as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-06-06 | — | — | EP | disclosed |
| US-6214879-B1 | Allosteric inhibitors of pyruvate kinase | VIRGINIA COMMONWEALTH UNIVERSITY | 2001-04-10 | — | — | US | disclosed |
| WO-1999048490-A1 | ALLOSTERIC INHIBITORS AND ACTIVATORS OF PYRUVATE KINASE | ALLOS THERAPEUTICS, INC. (US) | 1999-09-30 | — | — | WO | disclosed |
| US-5599974-A | ALDEHYDE AND ACID CONTAINING COMPOUNDS BOND WITH VALINE, ARGININE, AND LYSINE OF HEMOGLOBIN MOLECULE TO MODIFY MOLECULE | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1997-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209241-A1 | Benzoyl-piperazine derivatives | SLC1A2, SLC18A2, SLC6A7 | HMGB1 2385/4885CXCL12 3896/4885CTH 1927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.