SCHEMBL454989

SCHEMBL454989

CCc1ccc(N)c(O)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.68
KDM4E B2RXH2 2/20 0.68
GAA P10253 2/20 0.68
MAPT P10636 2/20 0.68
MEN1 O00255 1/20 0.68
RAB9A P51151 1/20 0.68
KMT2A Q03164 1/20 0.68
TRPA1 O75762 1/20 0.64
ALOX15 P16050 2/20 0.50
HSD17B10 Q99714 2/20 0.50
CYP3A4 P08684 1/20 0.50
NOS3 P29474 1/20 0.42
NOS1 P29475 1/20 0.42
NOS2 P35228 1/20 0.42
BACE1 P56817 1/20 0.41
DAO P14920 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2A6 P11509 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29631753 1.00 POLB (0.68) POLBKDM4EGAAMAPTMEN1
Hydrochloric Acid SCHEMBL9491995 0.98 KDM4E (0.65) POLBKDM4EGAAMAPTMEN1
Hydrochloric Acid SCHEMBL31134106 0.98 KDM4E (0.65) POLBKDM4EGAAMAPTMEN1
SCHEMBL14645890 0.90 RAB9A (0.57) POLBKDM4EGAAMAPTMEN1
Phosphoric Acid SCHEMBL5176868 0.90 GAA (0.57) POLBKDM4EGAAMAPTMEN1
SCHEMBL2786932 0.83 KDM4E (0.63) POLBKDM4EGAAMAPTMEN1
SCHEMBL1025691 0.82 TRPA1 (0.64) POLBKDM4EGAAMAPTMEN1
SCHEMBL13268461 0.82 TRPA1 (0.49) POLBKDM4EGAAMAPTMEN1
SCHEMBL436819 0.81 MAPT (1.00) POLBKDM4EGAAMAPTMEN1
SCHEMBL9008928 0.81 KDM4E (0.74) POLBKDM4EGAAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1475 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) WELLA GERMANY GMBH (DE) 2026-05-28 US claimed
US-12636241-B1 Method and composition for oxidative hair coloring WELLA OPERATIONS US LLC (US) 2026-05-26 US claimed
WO-2026104266-A1 USE OF A NATURAL OCCURRING POLYPHENOL AS AN OXIDATIVE COUPLER DYE PRECURSOR IN AN OXIDATIVE HAIR COLOURING COMPOSITION WELLA GERMANY GMBH (DE) 2026-05-21 WO claimed
EP-4739272-A1 OXIDATIVE HAIR COLOURING COMPOSITION Wella Germany GmbH (DE) 2026-05-13 EP claimed
US-12622853-B2 Composition comprising a particular oxidation dye precursor and a particular amino silicone L'OREAL (FR) 2026-05-12 US claimed
EP-4262720-B1 COMPOSITION COMPRISING TWO PARTICULAR OXIDATION DYE PRECURSORS, AND A PARTICULAR CARBOXYLIC ACID OREAL (FR) 2026-05-06 EP claimed
EP-4262716-B1 COMPOSITION COMPRISING A PARTICULAR OXIDATION DYE PRECURSOR AND A PARTICULAR CARBOXYLIC ACID OREAL (FR) 2026-05-06 EP claimed
EP-4734917-A1 COMPOSITION COMPRISING A PARTICULAR BASE AMMONIUM BICARBONATE AND FATTY ACID L'OREAL (FR) 2026-05-06 EP claimed
EP-4731170-A1 OXIDATIVE HAIR COLOURING COMPOSITION COMPRISING A CHELANT MIXTURE Wella Germany GmbH (DE) 2026-04-29 EP claimed
EP-4362892-B1 COMPOSITION COMPRISING AT LEAST ONE ALKYL (POLY)GLYCOSIDE, AT LEAST ONE FATTY ALCOHOL, AT LEAST ONE FATTY ACID, AND AT LEAST ONE ALKALINE AGENT OREAL (FR) 2026-04-15 EP claimed
EP-2103299-A2 Oxidizing hair colourant compositions The Procter and Gamble Company (US) 2009-09-23 EP claimed
US-20090119852-A1 Oxidizing Hair Colourant Compositions WELLA OPERATIONS US, LLC 2009-05-14 US claimed
WO-2009060334-A2 OXIDIZING HAIR COLOURANT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2009-05-14 WO claimed
CN-101312707-A Agent for colouring keratin fibres comprising 2-amino-5-methylphenol and m-aminophenol PROCTER & GAMBLE (US) 2008-11-26 CN claimed
EP-1926469-A1 AGENT TO COLOR KERATIN FIBERS CONTAINING 2-AMINO-5-METHYLPHENOL AND M-AMINOPHENOLES The Procter and Gamble Company (US) 2008-06-04 EP claimed
WO-2007034410-A1 AGENT TO COLOR KERATIN FIBERS CONTAINING 2-AMINO-5-METHYLPHENOL AND M-AMINOPHENOLES THE PROCTER & GAMBLE COMPANY (US) 2007-03-29 WO claimed
US-20070067926-A1 Agent for dyeing keratin fibers containing 2-amino-5-methyl-phenol and m-aminophenoles PROCTER & GAMBLE COMPANY, THE 2007-03-29 US claimed
EP-1558204-A1 MEANS FOR COLOURING KERATIN FIBRES COMPRISING 2-AMINO-5-ETHYLPHENOL Wella Aktiengesellschaft (DE) 2005-08-03 EP claimed
US-20050011016-A1 Means for colouring keratin fibres comprising 2-amino-5-ethylphenol WELLA AKTIENGESELLSCHAFT (DE) 2005-01-20 US claimed
WO-2004041225-A1 MEANS FOR COLOURING KERATIN FIBRES COMPRISING 2-AMINO-5-ETHYLPHENOL WELLA AKTIENGESELLSCHAFT (DE) 2004-05-21 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090119852-A1 Oxidizing Hair Colourant Compositions TET1, TET2, TET3 POLB 306/4885KDM4E 730/4885GAA 4642/4885
US-12636241-B1 Method and composition for oxidative hair coloring POLB, DAO, ALPP POLB 1/4885KDM4E 2019/4885GAA 4124/4885
US-20260144724-A1 Mixture of at least five surfactants (I1) to (I5) DEGS1, SGMS1, FABP4 POLB 2704/4885KDM4E 3739/4885GAA 2009/4885
US-12622853-B2 Composition comprising a particular oxidation dye precursor and a particular amino silicone KRT18, SCNN1B, PLOD3 POLB 45/4885KDM4E 784/4885GAA 4765/4885
US-20070067926-A1 Agent for dyeing keratin fibers containing 2-amino-5-methyl-phenol and m-aminophenoles KRT18, H1-5, H1-4 POLB 1462/4885KDM4E 112/4885GAA 4617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.