Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 7/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556755 | 0.87 | CNR2 (0.39) | CNR2DGAT1SCDHRH3ATR | |
| SCHEMBL4557042 | 0.79 | CNR2 (0.39) | CNR2TRPM8DGAT1CNR1 | |
| SCHEMBL8192205 | 0.74 | CNR2 (0.50) | CNR2CNR1HRH3ATRACHE | |
| SCHEMBL4445219 | 0.73 | TRPM8 (0.44) | CNR2TRPM8SCD | |
| SCHEMBL4450951 | 0.71 | SCD (0.53) | CNR2TRPM8SCD | |
| SCHEMBL13930227 | 0.70 | TRPM8 (0.39) | CNR2TRPM8SCDCNR1 | |
| SCHEMBL4556505 | 0.69 | TRPM8 (0.43) | TRPM8SCD | |
| SCHEMBL4443503 | 0.65 | DRD2 (0.43) | TRPM8SCD | |
| SCHEMBL20132904 | 0.65 | TRPM8 (0.43) | TRPM8SCD | |
| SCHEMBL13770570 | 0.64 | TRPM8 (0.49) | TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | claimed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |
| WO-2009037542-A2 | SPIROCYCLIC COMPOUNDS AS STEAROYL COA DESATURASE INHIBITORS | GLENMARK PHARMACEUTICALS, S.A. (US) | 2009-03-26 | — | — | WO | disclosed |