Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 8/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13666252 | 0.86 | GHSR (0.60) | CA12CA1CA2CA4CA5A | |
| SCHEMBL1462243 | 0.85 | CA12 (0.70) | CA12CA1CA2CA4CA5A | |
| SCHEMBL4302609 | 0.77 | MAOB (0.53) | GSTP1NR4A1NR4A2NR4A3MAOB | |
| SCHEMBL926213 | 0.76 | CA12 (0.70) | CA12CA1CA2CA4CA5A | |
| SCHEMBL7108878 | 0.75 | CA12 (0.74) | CA12CA1CA2CA4CA5A | |
| SCHEMBL9566532 | 0.75 | DHFR (0.73) | GSTP1NR4A1NR4A2NR4A3MAOB | |
| SCHEMBL4302606 | 0.74 | MAOB (0.50) | GSTP1NR4A1NR4A2NR4A3MAOB | |
| SCHEMBL9260073 | 0.74 | CA12 (0.72) | CA12CA1CA2CA4CA5A | |
| SCHEMBL28508086 | 0.74 | CA12 (0.72) | CA12CA1CA2CA4CA5A | |
| SCHEMBL7379441 | 0.74 | LMNA (0.59) | GSTP1NR4A1NR4A2NR4A3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7597980-B2 | Sulfonic acid group-containing, proton-conducting polymer composition, a solid electrolyte membrane and a solid polymer fuel cell | FUJITSU LIMITED (JP) | 2009-10-06 | — | — | US | disclosed |
| US-20050221135-A1 | Sulfonic acid group-containing, proton-conducting polymer composition, a solid electrolyte membrane and a solid polymer fuel cell | FUJITSU LIMITED (JP) | 2005-10-06 | — | — | US | disclosed |