SCHEMBL456141

SCHEMBL456141

CO[Si](C)(OC)OC=Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.44
NFE2L2 Q16236 2/20 0.40
MAOB P27338 1/20 0.39
CYP1A2 P05177 2/20 0.39
TUBB1 Q9H4B7 2/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39
TUBA4A P68366 1/20 0.39
TUBB4B P68371 1/20 0.39
TUBB3 Q13509 1/20 0.39
TUBB2A Q13885 1/20 0.39
TUBB8 Q3ZCM7 1/20 0.39
TUBA3E Q6PEY2 1/20 0.39
TUBA1A Q71U36 1/20 0.39
TUBA1C Q9BQE3 1/20 0.39
TUBB6 Q9BUF5 1/20 0.39
TUBB2B Q9BVA1 1/20 0.39
CYP1A1 P04798 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10682846 0.90 MAOB (0.44) TRPA1NFE2L2MAOBMEN1KMT2A
SCHEMBL7541641 0.82 TRPA1 (0.45) TRPA1NFE2L2MAOBCYP1A2TUBB1
SCHEMBL770392 0.81 MAOB (0.44) TRPA1NFE2L2MAOBMEN1KMT2A
SCHEMBL19548024 0.74 RELA (0.43) TRPA1MAOBCYP1A2MEN1KMT2A
SCHEMBL1899986 0.74 TRPA1 (0.38) TRPA1NFE2L2MAOBCMA1MEN1
SCHEMBL14681134 0.73 TRPA1 (0.54) TRPA1NFE2L2MAOBCYP1A2TUBB1
SCHEMBL14910 0.73 TRPA1 (0.54) TRPA1NFE2L2MAOBCYP1A2TUBB1
SCHEMBL1399923 0.73 TRPA1 (0.54) TRPA1NFE2L2MAOBCYP1A2TUBB1
SCHEMBL8996779 0.73 ALOX15 (0.39) TRPA1MAOBCYP1A2CMA1MEN1
SCHEMBL27748919 0.72 MAOB (0.44) TRPA1NFE2L2MAOBCYP1A2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9914809-B2 Moisture curable composition with amino acids MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2018-03-13 US claimed
US-9523002-B2 Moisture curable organopolysiloxane compositions MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2016-12-20 US claimed
EP-3102325-A1 MOISTURE CURABLE SILICONE COMPOSITION Momentive Performance Materials Inc. (US) 2016-12-14 EP claimed
US-20160347910-A1 CATALYST FOR SYNTHESIS OF SILOXANES MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2016-12-01 US claimed
EP-3074450-A1 MOISTURE CURABLE COMPOUND WITH METAL-ARENE COMPLEXES Momentive Performance Materials Inc. (US) 2016-10-05 EP claimed
US-20160244606-A1 CURABLE COATING COMPOSITIONS OF SILANE FUNCTIONAL POLYMERS KING INDUSTRIES 2016-08-25 US claimed
US-20160200875-A1 MOISTURE CURABLE COMPOSITIONS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2016-07-14 US claimed
EP-3036269-A1 MOISTURE CURABLE COMPOSITIONS Momentive Performance Materials Inc. (US) 2016-06-29 EP claimed
EP-3017002-A1 MOISTURE CURABLE COMPOSITIONS Momentive Performance Materials Inc. (US) 2016-05-11 EP claimed
EP-3010977-A2 MOISTURE CURABLE COMPOUND WITH THIOUREA Momentive Performance Materials Inc. (US) 2016-04-27 EP claimed
WO-2014186709-A1 CATALYST FOR SYNTHESIS OF SILOXANES MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-11-20 WO claimed
EP-2797986-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION Momentive Performance Materials Inc. (US) 2014-11-05 EP claimed
EP-2791265-A2 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS Momentive Performance Materials Inc. (US) 2014-10-22 EP claimed
EP-2791198-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS Momentive Performance Materials Inc. (US) 2014-10-22 EP claimed
EP-2776162-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION Momentive Performance Materials Inc. (US) 2014-09-17 EP claimed
WO-2013101751-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION MOMENTIVE PERFORMANCE MATERIALS, INC. (US) 2013-07-04 WO claimed
WO-2013090127-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS MOMENTIVE PERFORMANCE MATERIALS, INC. (US) 2013-06-20 WO claimed
WO-2013090132-A2 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITIONS MOMENTIVE PERFORMANCE MATERIALS, INC. (US) 2013-06-20 WO claimed
WO-2013070227-A1 MOISTURE CURABLE COMPOSITION OF A POLYMER HAVING SILYL GROUPS MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-05-16 WO claimed
WO-2013071078-A1 MOISTURE CURABLE ORGANOPOLYSILOXANE COMPOSITION MOMENTIVE PERFORMANCE MATERIALS, INC. (US) 2013-05-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160200875-A1 MOISTURE CURABLE COMPOSITIONS RNMT, DOT1L, SAT1 TRPA1 779/4885NFE2L2 2948/4885MAOB 1875/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.