Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3602535 | 0.86 | HRH3 (0.37) | KCNH2HRH3FFAR4 | |
| SCHEMBL3602166 | 0.77 | GPR119 (0.49) | — | |
| SCHEMBL3607859 | 0.74 | CYP2D6 (0.38) | POLBRIPK1 | |
| SCHEMBL3605764 | 0.74 | RAB9A (0.39) | — | |
| SCHEMBL4593696 | 0.71 | GPR119 (0.34) | — | |
| SCHEMBL8511076 | 0.70 | DGAT1 (0.45) | KCNH2 | |
| SCHEMBL4616891 | 0.70 | GPR119 (0.31) | — | |
| SCHEMBL28053867 | 0.70 | OPRK1 (0.41) | KCNH2POLB | |
| SCHEMBL4593318 | 0.69 | LOXL2 (0.30) | — | |
| SCHEMBL3252707 | 0.69 | HRH1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121703-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008020799-A1 | THIENOPYRIMIDIN-4-ONE AND THIENOPYRIDAZIN-7-ONE DERIVATIVES AS MCH RL ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |