SCHEMBL456924

SCHEMBL456924

Nc1ccc(NCc2cccs2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.69
PTPN1 P18031 1/20 0.54
PTPN11 Q06124 1/20 0.54
KDM4E B2RXH2 6/20 0.53
ALDH1A1 P00352 5/20 0.53
GAA P10253 3/20 0.53
MAPT P10636 3/20 0.53
FYN P06241 1/20 0.48
MEN1 O00255 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
KMT2A Q03164 1/20 0.48
KCNH3 Q9ULD8 2/20 0.48
POLB P06746 2/20 0.47
TAAR1 Q96RJ0 1/20 0.47
SMN1; SMN2 Q16637 5/20 0.47
NPC1 O15118 4/20 0.47
RAB9A P51151 4/20 0.47
HTT P42858 1/20 0.47
TSHR P16473 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6298735 0.98 L3MBTL1 (0.67) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
SCHEMBL2716691 0.82 L3MBTL1 (0.70) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
SCHEMBL7955725 0.82 L3MBTL1 (0.65) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
SCHEMBL4847201 0.82 TAAR1 (0.53) L3MBTL1MAPTMEN1KMT2AKCNH3
SCHEMBL8782898 0.81 L3MBTL1 (0.69) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
SCHEMBL8322277 0.81 L3MBTL1 (0.69) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
Hydrochloric Acid SCHEMBL4843147 0.81 TAAR1 (0.52) L3MBTL1KDM4EALDH1A1GAAMAPT
SCHEMBL1417373 0.81 L3MBTL1 (0.54) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
SCHEMBL14849565 0.81 MAPT (0.63) L3MBTL1PTPN1PTPN11KDM4EALDH1A1
Hydrochloric Acid SCHEMBL456056 0.80 KDM4E (0.55) L3MBTL1PTPN1PTPN11KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1752192-B1 Oxidizing hair coloring agents containing m-Aminophenol derivatives PROCTER & GAMBLE (US) 2010-02-03 EP claimed
US-20070067923-A1 1,3-Diaminobenzene derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-03-29 US claimed
EP-1760072-A1 1,3-diaminobenzene derivatives and colorants comprising these compounds Wella Aktiengesellschaft (DE) 2007-03-07 EP claimed
WO-2007020565-A1 OXIDIZING HAIR COLORING AGENTS CONTAINING M-AMINOPHENOL DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 2007-02-22 WO claimed
US-20070033745-A1 Developer substance-coupler substance of 3-(1-pyrrolidinyl)phenol and 1,4-diaminobenzene PROCTER & GAMBLE COMPANY, THE 2007-02-15 US claimed
EP-1752192-A1 Oxidizing hair coloring agents containing m-Aminophenol derivatives Wella Aktiengesellschaft (DE) 2007-02-14 EP claimed
US-20070022546-A1 3-Amino-2-aminomethylphenol derivatives and colorants comprising these compounds PROCTER & GAMBLE COMPANY, THE 2007-02-01 US claimed
US-6887281-B2 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds WELLA AKTIENGESELLSCHAFT (DE) 2005-05-03 US claimed
US-6849097-B2 N-heteroarylmethyl-p-phnylendiamine derivatives and compounds containing oxidationcoloring agents WELLA AKTIENGESELLSCHAFT (DE) 2005-02-01 US claimed
US-20050015898-A1 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2005-01-27 US claimed
EP-1313724-B1 N-HETEROARYLMETHYL-P-PHENYLENDIAMINE DERIVATIVES AND COMPOUNDS CONTAINING OXIDATION COLOURING AGENTS WELLA AG (DE) 2004-04-28 EP claimed
EP-1313724-A1 N-HETEROARYLMETHYL-P-PHENYLENDIAMINE DERIVATIVES AND COMPOUNDS CONTAINING OXIDATION COLOURING AGENTS Wella Aktiengesellschaft (DE) 2003-05-28 EP claimed
US-20030070240-A1 N-heteroarylmethyl-p-phnylendiamine derivatives and compounds containing oxidationcoloring agents HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2003-04-17 US claimed
WO-2002018365-A1 N-HETEROARYLMETHYL-P-PHENYLENDIAMINE DERIVATIVES AND COMPOUNDS CONTAINING OXIDATION COLOURING AGENTS WELLA AKTIENGESELLSCHAFT (DE) 2002-03-07 WO claimed
US-12133906-B2 Delivery particle THE PROCTER & GAMBLE COMPANY (US) 2024-11-05 US disclosed
US-20220409497-A1 DELIVERY PARTICLE PROCTER & GAMBLE (US) 2022-12-29 US disclosed
EP-3733827-A1 DELIVERY PARTICLES The Procter & Gamble Company (US) 2020-11-04 EP disclosed
EP-1313724-A1 N-HETEROARYLMETHYL-P-PHENYLENDIAMINE DERIVATIVES AND COMPOUNDS CONTAINING OXIDATION COLOURING AGENTS Wella Aktiengesellschaft (DE) 2003-05-28 EP disclosed
US-20030070240-A1 N-heteroarylmethyl-p-phnylendiamine derivatives and compounds containing oxidationcoloring agents HFC PRESTIGE INTERNATIONAL OPERATIONS SWITZERLAND SÀRL (CH) 2003-04-17 US disclosed
WO-2002018365-A1 N-HETEROARYLMETHYL-P-PHENYLENDIAMINE DERIVATIVES AND COMPOUNDS CONTAINING OXIDATION COLOURING AGENTS WELLA AKTIENGESELLSCHAFT (DE) 2002-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220409497-A1 DELIVERY PARTICLE LIPA, CHMP4B, SLC46A1 L3MBTL1 4429/4885PTPN1 3816/4885PTPN11 4027/4885
US-20070022546-A1 3-Amino-2-aminomethylphenol derivatives and colorants comprising these compounds KRT18, COL2A1, COL1A1 L3MBTL1 4293/4885PTPN1 3862/4885PTPN11 3710/4885
US-20030070240-A1 N-heteroarylmethyl-p-phnylendiamine derivatives and compounds containing oxidationcoloring agents PNMT, PAH, CYP2E1 L3MBTL1 3680/4885PTPN1 1216/4885PTPN11 2036/4885
US-20070067923-A1 1,3-Diaminobenzene derivatives and colorants comprising these compounds KRT18, DSP, DSG1 L3MBTL1 4395/4885PTPN1 1070/4885PTPN11 1219/4885
US-20070033745-A1 Developer substance-coupler substance of 3-(1-pyrrolidinyl)phenol and 1,4-diaminobenzene TACR1, KRT18, AKR1C4 L3MBTL1 4839/4885PTPN1 3054/4885PTPN11 3906/4885
US-12133906-B2 Delivery particle LIPA, CHMP4B, SLC46A1 L3MBTL1 4429/4885PTPN1 3816/4885PTPN11 4027/4885
US-20050015898-A1 N-heteroarylmethyl-p-phenylenediamine derivatives as well as oxidation dyeing agents containing these compounds TYR, PNMT, DDT L3MBTL1 4322/4885PTPN1 1170/4885PTPN11 1687/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.