SCHEMBL457105

SCHEMBL457105

Cc1nc2ncnn2c(O)c1Br

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.44
HSD17B10 Q99714 2/20 0.43
TSHR P16473 2/20 0.41
ENPP1 P22413 3/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
USP2 O75604 1/20 0.39
MBOAT4 Q96T53 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 3/20 0.37
MAPK1 P28482 2/20 0.37
PKM P14618 1/20 0.37
HPGD P15428 1/20 0.37
MAPT P10636 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7597284 0.98 ALDH1A1 (0.43) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL7553783 0.89 LMNA (0.43) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL5199168 0.81 TSHR (0.50) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL9824226 0.79 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL6264484 0.79 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRENPP1USP2
SCHEMBL7117782 0.79 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL24129443 0.77 ENPP1 (0.56) ALDH1A1ENPP1
SCHEMBL9770335 0.77 HSD17B10 (0.56) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL5197330 0.76 MEN1 (0.55) ALDH1A1HSD17B10TSHRENPP1L3MBTL1
SCHEMBL5672150 0.75 TSHR (0.41) ALDH1A1HSD17B10TSHRENPP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0213964-B1 SILVER HALIDE PHOTOGRAPHIC EMULSIONS WITH NOVEL GRAIN FACES (3) EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1991-07-31 EP claimed
US-4684607-A Tabular silver halide emulsions with ledges EASTMAN KODAK COMPANY (US) 1987-08-04 US claimed
US-4680256-A Emulsions and photographic elements containing silver halide grains having trisoctahedra crystal faces EASTMAN KODAK COMPANY (US) 1987-07-14 US claimed
EP-0213964-A2 Silver halide photographic emulsions with novel grain faces (3) EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1987-03-11 EP claimed
US-20250368654-A1 HETEROCYCLIC INHIBITORS OF ENPP1 VOLASTRA THERAPEUTICS, INC. (US) 2025-12-04 US disclosed
US-20240376113-A1 HETEROCYCLIC INHIBITORS OF ENPP1 VOLASTRA THERAPEUTICS, INC. (US) 2024-11-14 US disclosed
US-20230036933-A1 HETEROCYCLIC INHIBITORS OF ENPP1 VOLASTRA THERAPEUTICS, INC. (US) 2023-02-02 US disclosed
WO-2021257614-A1 HETEROCYCLIC INHIBITORS OF ENPP1 VOLASTRA THERAPEUTICS, INC. (US) 2021-12-23 WO disclosed
WO-2021257614-A1 HETEROCYCLIC INHIBITORS OF ENPP1 VOLASTRA THERAPEUTICS, INC. (US) 2021-12-23 WO disclosed
US-8409792-B2 Color intermediate motion picture film EAST KODAK COMPANY (US) 2013-04-02 US disclosed
US-20120064464-A1 RADIOGRAPHIC SILVER HALIDE FILMS HAVING INCORPORATED DEVELOPER CARESTREAM HEALTH, INC. 2012-03-15 US disclosed
EP-2411872-A1 RADIOGRAPHIC SILVER HALIDE FILMS HAVING INCORPORATED DEVELOPER Carestream Health, Inc. (US) 2012-02-01 EP disclosed
US-4221864-A CONTRAST, SENSITIZERS KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1980-09-09 US disclosed
US-4211835-A TETRAZOLIUM COMPOUND, BLACK AND WHITE, HIGH CONTRAST KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1980-07-08 US disclosed
US-4210715-A TETRAZOLIUM COMPOUND AND SENSITIZING DYE KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1980-07-01 US disclosed
US-4192682-A NON-DIFFUSIBLE COMPOUND HAVING OXIDATION POWER ON A HYDROQUINONE DEVELOPING AGENT; DEVELOPER CONTAINING NO HYDROQUINONE KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1980-03-11 US disclosed
US-4175966-A NONDIFFUSING COMPOUND CAPABLE OF OXIDIZING HYDROQUINONE DEVELOPING AGENT KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1979-11-27 US disclosed
US-4169733-A PRETREATMENT WITH NITROGEN HETEROCYCLE SUBSTITUTED WITH MERCAPTO, THIOKETONE OR THIOETHER GROUP OF SILVER HALIDE EMULSION CONTAINING A TETRAZOLIUM COMPOUND KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1979-10-02 US disclosed
US-4144070-A SUPERSENSITIZING DYES KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1979-03-13 US disclosed
US-4075021-A COMPOUND WHICH RELEASES A SUBSTANCE WHICH PROMOTES BLEACHING OF DEVELOPED SILVER KONISHIROKU PHOTO INDUSTRY CO., LTD. (JA) 1978-02-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230036933-A1 HETEROCYCLIC INHIBITORS OF ENPP1 ENPP1, ENPP3, ENPP2 ALDH1A1 2792/4885HSD17B10 2304/4885TSHR 3601/4885
US-20250368654-A1 HETEROCYCLIC INHIBITORS OF ENPP1 ENPP1, ENPP3, ENPP2 ALDH1A1 2792/4885HSD17B10 2304/4885TSHR 3601/4885
US-20240376113-A1 HETEROCYCLIC INHIBITORS OF ENPP1 ENPP1, ENPP3, ENPP2 ALDH1A1 2792/4885HSD17B10 2304/4885TSHR 3601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.