Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454919 | 0.80 | ESR2 (0.35) | HRH1CYP2A6CYP2B6ALDH1A1MAPT | |
| SCHEMBL456741 | 0.75 | KDM4E (0.31) | HRH1ALDH1A1MAPTNPSR1 | |
| SCHEMBL7820403 | 0.74 | PDE4B (0.38) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL456629 | 0.74 | SQOR (0.39) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL458401 | 0.73 | SQOR (0.34) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL455612 | 0.73 | ALDH1A1 (0.38) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL457574 | 0.73 | SQOR (0.38) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL21331773 | 0.71 | BACE1 (0.42) | PDE4DBACE1SQORPDE4BPDE4A | |
| SCHEMBL456986 | 0.71 | PDE4B (0.33) | PDE4DSLC6A3BACE1SQORHRH1 | |
| SCHEMBL457181 | 0.68 | ADRB2 (0.33) | PDE4DBACE1SQORPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614053-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012033225-A1 | METHOD FOR PRODUCING PYRIDAZINONE COMPOUNDS AND INTERMEDIATE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-03-15 | — | — | WO | disclosed |