Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.40 |
| ▸ | HTR2A | P28223 | 13/20 | 0.40 |
| ▸ | DRD3 | P35462 | 13/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8100150 | 0.75 | CTSB (0.61) | — | |
| SCHEMBL4573200 | 0.72 | CTSK (0.57) | — | |
| SCHEMBL4573950 | 0.71 | CTSS (0.45) | — | |
| SCHEMBL4573111 | 0.70 | USP30 (0.47) | DRD2NAMPT | |
| SCHEMBL4589748 | 0.70 | CTSB (0.54) | — | |
| SCHEMBL4573253 | 0.70 | CTSK (0.39) | — | |
| SCHEMBL4573015 | 0.69 | CTSK (0.38) | — | |
| SCHEMBL4584329 | 0.69 | HRH3 (0.40) | — | |
| SCHEMBL15971640 | 0.69 | HTR2C (0.61) | DRD2HTR2ADRD3HTR2CNAMPT | |
| SCHEMBL4573371 | 0.69 | HSD11B1 (0.48) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |