Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575085 | 1.00 | RIPK1 (0.38) | RIPK1HTR2CHTR2AHTR2BDPP4 | |
| SCHEMBL4590891 | 0.78 | SIGMAR1 (0.43) | RIPK1 | |
| SCHEMBL4574455 | 0.74 | KDM4E (0.44) | KCNH2CYP1A2KMT2A | |
| SCHEMBL29050285 | 0.74 | ALDH1A1 (0.44) | KCNH2KMT2A | |
| SCHEMBL4574384 | 0.71 | RIPK1 (0.43) | RIPK1DPP4 | |
| SCHEMBL4591030 | 0.71 | RIPK1 (0.43) | RIPK1DPP4 | |
| SCHEMBL4591026 | 0.71 | RIPK1 (0.43) | RIPK1DPP4 | |
| SCHEMBL2022959 | 0.70 | XIAP (0.40) | CYP3A4 | |
| SCHEMBL20818079 | 0.70 | LMNA (0.56) | HTR2CDPP4KCNH2KMT2A | |
| SCHEMBL26192287 | 0.69 | ALDH1A1 (0.54) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| WO-2008134035-A1 | ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |