Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242555 | 0.91 | CCR5 (0.31) | CCR5 | |
| SCHEMBL4581928 | 0.90 | CYP2C19 (0.38) | AKT1CYP2C19HTR6PIK3C3 | |
| SCHEMBL8242925 | 0.74 | PIK3C3 (0.42) | AKT1CYP2C19HTR6PIK3C3 | |
| SCHEMBL8233993 | 0.74 | AKT1 (0.45) | AKT1HTR6PIK3C3 | |
| SCHEMBL4584318 | 0.72 | PIK3C3 (0.31) | CYP2C19PIK3C3 | |
| SCHEMBL12346679 | 0.71 | L3MBTL1 (0.40) | CYP2C19HTR6PIK3C3 | |
| SCHEMBL4633196 | 0.70 | CYP2C19 (0.46) | CYP2C19HTR6PIK3C3 | |
| SCHEMBL4583522 | 0.70 | AKT1 (0.41) | AKT1CYP2C19PIK3C3 | |
| SCHEMBL8244308 | 0.70 | SCN9A (0.42) | AKT1 | |
| SCHEMBL4592678 | 0.69 | AKT1 (0.46) | AKT1CYP2C19PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |