Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403099 | 0.84 | ALDH1A1 (0.45) | VDRDHODHALDH1A1CYP3A4KMT2A | |
| SCHEMBL14318318 | 0.84 | VDR (0.52) | VDRMMP2MMP9DHODHALDH1A1 | |
| SCHEMBL28367938 | 0.82 | KMT2A (0.57) | VDRMMP2MMP9DHODHALDH1A1 | |
| SCHEMBL26286109 | 0.80 | CCR5 (0.44) | VDRDHODHALDH1A1CYP3A4KMT2A | |
| SCHEMBL4583291 | 0.79 | PKM (0.42) | VDRDHODHALDH1A1CYP3A4CYP2C19 | |
| SCHEMBL19725071 | 0.78 | CA2 (0.44) | ALDH1A1CYP3A4KMT2APKMLMNA | |
| SCHEMBL1031702 | 0.77 | ALDH1A1 (0.44) | VDRDHODHALDH1A1CYP3A4PKM | |
| SCHEMBL1032100 | 0.77 | ALDH1A1 (0.44) | VDRDHODHALDH1A1CYP3A4PKM | |
| SCHEMBL1031704 | 0.77 | ALDH1A1 (0.44) | VDRDHODHALDH1A1CYP3A4PKM | |
| SCHEMBL23624813 | 0.77 | ALDH1A1 (0.40) | VDRDHODHALDH1A1CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |