SCHEMBL458573

SCHEMBL458573

CC(C)(C)OC(=O)NC1CC=CC1

nearest known ligand 0.51

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
BTK Q06187 1/20 0.51
NFKB1 P19838 4/20 0.49
NFKB2 Q00653 4/20 0.49
RELA Q04206 4/20 0.49
EPHX2 P34913 1/20 0.48
CTSK P43235 2/20 0.47
GAA P10253 2/20 0.46
KDM1A O60341 2/20 0.44
MAOB P27338 1/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
KMT2A Q03164 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
EPHX1 P07099 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1783880 0.88 BTK (0.51) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL471719 0.88 BTK (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL471720 0.88 BTK (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL508784 0.88 BTK (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL763965 0.84 NFKB1 (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL4270316 0.84 NFKB1 (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL20063806 0.84 NFKB1 (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL4270314 0.84 NFKB1 (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL21294876 0.84 NFKB1 (0.49) BTKNFKB1NFKB2RELAEPHX2
SCHEMBL31650782 0.81 BTK (0.47) BTKNFKB1NFKB2RELAEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 434 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116023945-B Etching liquid composition, etching liquid and preparation method thereof 浙江奥首材料科技有限公司 2024-06-07 CN claimed
CN-116023945-A Etching liquid composition, etching liquid and preparation method thereof 浙江奥首材料科技有限公司 2023-04-28 CN claimed
EP-4709389-A1 HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 Celgene Corporation (US) 2026-03-18 EP disclosed
EP-4680607-A1 BICYCLIC UREAS AS KINASE INHIBITORS Incyte Corporation (US) 2026-01-21 EP disclosed
EP-4577520-A1 PEGYLATED LIPID COMPOUNDS AND METHODS OF USE THEREOF Renagade Therapeutics Management Inc. (US) 2025-07-02 EP disclosed
WO-2025133989-A1 SMYD MODULATORS AND USES THEREOF ALT-BIO PTE. LTD. (SG) 2025-06-26 WO disclosed
WO-2024233747-A1 HETEROARYL COMPOUNDS AS LIGAND DIRECTED DEGRADERS OF IRAK4 CELGENE CORPORATION (US) 2024-11-14 WO disclosed
US-20240336593-A1 Compound Having Antitumor Activity And Use Thereof INNOVSTONE THERAPEUTICS LIMITED (CN) 2024-10-10 US disclosed
US-20240317744-A1 Bicyclic Ureas As Kinase Inhibitors INCYTE CORPORATION 2024-09-26 US disclosed
WO-2024191996-A1 BICYCLIC UREAS AS KINASE INHIBITORS INCYTE CORPORATION (US) 2024-09-19 WO disclosed
CN-116023945-B Etching liquid composition, etching liquid and preparation method thereof 浙江奥首材料科技有限公司 2024-06-07 CN disclosed
WO-2008042353-A1 POTENT AND HIGHLY SELECTIVE HETEROAROMATIC INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE NORTHWESTERN UNIVERSITY (US) 2008-04-10 WO disclosed
EP-1670478-A2 HETEROAROMATIC SELECTIVE INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE NORTHWESTERN UNIVERSITY (US) 2006-06-21 EP disclosed
US-7037916-B2 Pyrimidine derivatives as IL-8 receptor antagonists PHARMACOPEIA DRUG DISCOVERY, INC. (US) 2006-05-02 US disclosed
US-20050107369-A1 Heteroaromatic selective inhibitors of neuronal nitric oxide synthase NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-05-19 US disclosed
WO-2005026111-A2 HETEROAROMATIC SELECTIVE INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE NORTHWESTERN UNIVERSITY (US) 2005-03-24 WO disclosed
WO-2004062609-A2 PYRIMIDINE DERIVATIVES AS IL-8 RECEPTOR ANTAGONISTS PHARMACOPEIA, INC. (US) 2004-07-29 WO disclosed
US-20040087601-A1 Pyrimidine derivatives as IL-8 receptor antagonists PHARMACOPEIA, LLC 2004-05-06 US disclosed
US-5998398-A HERPES VIRUS GLAXO WELLCOME INC. (US) 1999-12-07 US disclosed
CN-1212683-A 2-amino-5,6-dichlorobenzimidazole derivatives having antiviral activity GLAXO GROUP LTD (GB) 1999-03-31 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050107369-A1 Heteroaromatic selective inhibitors of neuronal nitric oxide synthase NOS1, NOS2, NOS3 BTK 4472/4885NFKB1 2529/4885NFKB2 2620/4885
US-20040087601-A1 Pyrimidine derivatives as IL-8 receptor antagonists CXCL8, IL1RN, IL18 BTK 1201/4885NFKB1 391/4885NFKB2 339/4885
US-20240336593-A1 Compound Having Antitumor Activity And Use Thereof PRMT5, PRMT1, PRMT6 BTK 1274/4885NFKB1 1054/4885NFKB2 2493/4885
US-20240317744-A1 Bicyclic Ureas As Kinase Inhibitors JAK2, UCK2, ULK2 BTK 63/4885NFKB1 1168/4885NFKB2 1060/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.