2-Pyrrolidone

2-Pyrrolidone

SCHEMBL4595907

C=COC(C)=O.C=COC(C)=O.C=COC(C)=O.C=COC(C)=O.O=C1CCCN1.O=C1CCCN1.O=C1CCCN1.O=C1CCCN1.O=C1CCCN1.O=C1CCCN1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
OR51E2 Q9H255 1/20 0.52
CRBN Q96SW2 2/20 0.45
FKBP5 Q13451 1/20 0.45
KDM4E B2RXH2 2/20 0.34
GAA P10253 1/20 0.34
POLB P06746 1/20 0.34
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
GFER P55789 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Pyrrolidone SCHEMBL22534 1.00 OR51E2 (0.52) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL933908 0.98 OR51E2 (0.50) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL28565455 0.98 OR51E2 (0.50) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL27876042 0.95 OR51E2 (0.47) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL852356 0.91 OR51E2 (0.43) OR51E2CRBNFKBP5ALDH1A1
Caprolactam SCHEMBL28156132 0.88 FKBP5 (0.46) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL27365042 0.85 OR51E2 (0.47) OR51E2CRBNFKBP5KDM4EGAA
Itaconate SCHEMBL4960729 0.85 ALOX15 (0.40) OR51E2CRBNFKBP5
2-Pyrrolidone SCHEMBL28279632 0.83 OR51E2 (0.48) OR51E2CRBNFKBP5KDM4EGAA
2-Pyrrolidone SCHEMBL3378461 0.83 OR51E2 (0.52) OR51E2CRBNFKBP5KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1629975-B1 Planographic printing plate precursor and method of making planographic printing plate FUJIFILM CORP (JP) 2008-01-02 EP disclosed
EP-1715386-A1 Replenisher for photosensitive planographic printing plate and plate making method using the same Fuji Photo Film Co., Ltd. (JP) 2006-10-25 EP disclosed
US-20060046185-A1 Planographic printing plate precursor and method of making planographic printing plate FUJI PHOTO FILM CO., LTD. 2006-03-02 US disclosed
EP-1629975-A1 Planographic printing plate precursor and method of making planographic printing plate FUJI PHOTO FILM CO., LTD. (JP) 2006-03-01 EP disclosed