Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1972818 | 0.84 | NPC1 (0.41) | KDM4EKMT2ANPC1RAB9AMAPT | |
| SCHEMBL5067720 | 0.81 | ALDH1A1 (0.40) | NPC1RAB9AMAPTALDH1A1CDK1 | |
| SCHEMBL11785225 | 0.80 | ALDH1A1 (0.38) | KDM4EKMT2ANPC1RAB9AMAPT | |
| SCHEMBL7999620 | 0.73 | BRD4 (0.37) | KDM4ECYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL2230518 | 0.71 | ALDH1A1 (0.35) | KDM4ECYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL8697262 | 0.70 | NPC1 (0.42) | KDM4EKMT2ANPC1RAB9AMAPT | |
| SCHEMBL694769 | 0.70 | LMNA (0.44) | KMT2AMEN1ALDH1A1HPGDIDO1 | |
| SCHEMBL1492649 | 0.70 | CYP19A1 (0.51) | KDM4ECYP1A2KMT2ANPC1RAB9A | |
| SCHEMBL10767218 | 0.67 | PDE5A (0.38) | KDM4EKMT2ANPC1RAB9AMAPT | |
| SCHEMBL6336392 | 0.67 | RAB9A (0.53) | KDM4ECYP1A2KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287726-A1 | 5-Substituted 1H-Pyrrolo [3,2-B] Pyridines | ALTANA PHARMA AG (DE) | 2007-12-13 | — | — | US | claimed |
| EP-1776361-A1 | 5-SUBSTITUTED 1H-PYRROLOÝ3,2-B¨PYRIDINES | Altana Pharma AG (DE) | 2007-04-25 | — | — | EP | claimed |
| WO-2006013195-A1 | 5-SUBSTITUTED 1H-PYRROLO[3,2-B]PYRIDINES | ALTANA PHARMA AG (DE) | 2006-02-09 | — | — | WO | claimed |
| US-20080280855-A1 | Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles | NYCOMED GMBH (DE) | 2008-11-13 | — | — | US | disclosed |
| WO-2008074858-A1 | INTERMEDIATES AND PROCESS FOR THE PRODUCTION OF 5-SUBSTITUTED TRICYCLIC BENZIMIDAZOLES | NYCOMED GMBH (DE) | 2008-06-26 | — | — | WO | disclosed |
| US-20080113963-A1 | Cyclic benzimidazoles | ALTANA PHARMA AG (DE) | 2008-05-15 | — | — | US | disclosed |
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| US-20080113962-A1 | Condensed Tricyclic Benzimidazoles For the Treatment of Gastrointestinal Disorders | AITANA PHARMA AG (DE) | 2008-05-15 | — | — | US | disclosed |
| EP-1718648-B1 | TRICYCLIC IMIDAZOPYRIDINES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF | NYCOMED GMBH (DE) | 2008-04-23 | — | — | EP | disclosed |
| EP-1904454-A2 | PROCESS FOR THE PRODUCTION OF INTERMADIATES FOR THE PREPARATION OF TRICYCLIC BENZIMIDAZOLES | Nycomed GmbH (DE) | 2008-04-02 | — | — | EP | disclosed |
| US-20080033006-A1 | 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors | ALTANA PHARMA AG (DE) | 2008-02-07 | — | — | US | disclosed |
| WO-2003091253-A1 | NITROSATED IMIDAZOPYRIDINES | ALTANA PHARMA AG (DE) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003068774-A1 | TRICYCLIC N-ACYL COMPOUNDS | ALTANA PHARMA AG (DE) | 2003-08-21 | — | — | WO | disclosed |
| EP-1332143-A1 | POLYSUBSTITUTED IMIDAZOPYRIDINES AS GASTRIC SECRETION INHIBITORS | ALTANA Pharma AG (DE) | 2003-08-06 | — | — | EP | disclosed |
| WO-2003016310-A1 | ALKYL-SUBSTITUTED IMIDAZOPYRIDINES FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS | ALTANA PHARMA AG (DE) | 2003-02-27 | — | — | WO | disclosed |
| WO-2003014123-A1 | TRICYCLIC IMIDAZOPYRIDINES | ALTANA PHARMA AG (DE) | 2003-02-20 | — | — | WO | disclosed |
| WO-2003014120-A1 | AMINO-SUBSTITUTED IMIDAZOPYRIDINES FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | ALTANA PHARMA AG (DE) | 2003-02-20 | — | — | WO | disclosed |
| WO-2003014119-A1 | TRICYCLIC EPOXIDES | ALTANA PHARMA AG (DE) | 2003-02-20 | — | — | WO | disclosed |
| WO-2003004480-A2 | SUBSTITUTED PIPERAZINE AND DIAZEPANES AS HISTAMINE H3 RECEPTOR AGONISTS | NOVO NORDISK A/S (DK) | 2003-01-16 | — | — | WO | disclosed |
| WO-2002034749-A1 | POLYSUBSTITUTED IMIDAZOPYRIDINES AS GASTRIC SECRETION INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113962-A1 | Condensed Tricyclic Benzimidazoles For the Treatment of Gastrointestinal Disorders | PGC, SI, VIP | KDM4E 3631/4885CYP1A2 560/4885KMT2A 3003/4885 |
| US-20070287726-A1 | 5-Substituted 1H-Pyrrolo [3,2-B] Pyridines | GIPR, VIP, PGC | KDM4E 2549/4885CYP1A2 301/4885KMT2A 4679/4885 |
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | KDM4E 1567/4885CYP1A2 1124/4885KMT2A 295/4885 |
| US-20080033006-A1 | 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors | CCKBR, GIPR, PGA5 | KDM4E 2527/4885CYP1A2 250/4885KMT2A 2766/4885 |
| US-20080113963-A1 | Cyclic benzimidazoles | VIP, GIPR, SI | KDM4E 3472/4885CYP1A2 275/4885KMT2A 4735/4885 |
| US-20080280855-A1 | Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles | CYP1B1, CYP1A1, CYP3A4 | KDM4E 2195/4885CYP1A2 7/4885KMT2A 2360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.