SCHEMBL460152

SCHEMBL460152

C=CCC1=CC(=O)N(CC=C)C1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 1/20 0.40
POLB P06746 4/20 0.38
ALDH1A1 P00352 8/20 0.36
CYP3A4 P08684 1/20 0.35
CA12 O43570 3/20 0.33
CA9 Q16790 3/20 0.33
RXFP1 Q9HBX9 1/20 0.33
GAA P10253 2/20 0.32
TSHR P16473 1/20 0.32
MAPT P10636 5/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
MEN1 O00255 4/20 0.31
KMT2A Q03164 4/20 0.31
PKM P14618 3/20 0.31
LMNA P02545 2/20 0.31
KDM4E B2RXH2 1/20 0.31
HTT P42858 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
CNR1 P21554 1/20 0.31
GALR3 O60755 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5323456 0.76 ACHE (0.39) CASP3MEN1KMT2AUSP2
SCHEMBL9414033 0.74
SCHEMBL488020 0.74
SCHEMBL1955693 0.74
SCHEMBL8443692 0.74 CASP3 (0.44) CASP3POLBALDH1A1CYP3A4CA12
SCHEMBL4853663 0.74 RGS4 (0.49) CASP3POLBALDH1A1CYP3A4CA12
SCHEMBL756294 0.70
SCHEMBL7038598 0.69 CASP3 (0.54) CASP3POLBALDH1A1CYP3A4CA12
SCHEMBL5318341 0.68 RGS4 (0.50) CASP3POLBALDH1A1CA12CA9
SCHEMBL9615214 0.68 MGLL (0.41) CASP3ALDH1A1GAAL3MBTL1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8609745-B2 Production of ophthalmic devices based on photo-induced step growth polymerization NOVARTIS AG (CH) 2013-12-17 US claimed
EP-2379628-B1 STABILIZERS FOR FLAME RETARDANT POLYMERS CONTAINING ALIPHATICALLY-BOUND BROMINE DOW GLOBAL TECHNOLOGIES LLC (US) 2013-08-21 EP claimed
US-20130106007-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION NOVARTIS AG (CH) 2013-05-02 US claimed
US-20110269869-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION ALCON INC. (CH) 2011-11-03 US claimed
EP-2092376-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION Novartis Ag (CH) 2009-08-26 EP claimed
WO-2008076729-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION NOVARTIS AG (CH) 2008-06-26 WO claimed
US-20080143958-A1 Production of ophthalmic devices based on photo-induced step growth polymerization ALCON INC. (CH) 2008-06-19 US claimed
US-20050277061-A1 Polymeric material for laser processing and a laminated body for laser processing thereof, flexographic printing plate and the method of producing the same, and a seal material JSR CORPORATION (JP) 2005-12-15 US claimed
EP-1101608-B1 Articles having imageable coatings KODAK POLYCHROME GRAPHICS CO (US) 2005-01-19 EP claimed
EP-0255601-B1 DIALKYLNALEINIMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDE NIHON BAYER AGROCHEM K.K. (JP) 1991-09-11 EP claimed
US-4729784-A 1-(1,4-benzoxazin-3-on-6-yl)-dialkylmaleimides and use as herbicides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1988-03-08 US claimed
US-4585848-A HIGH STRENGTH, SOLVENT RESISTANCE EVANS EDWIN R (US) 1986-04-29 US claimed
US-4459305-A INSECTICIDE, MITICIDE DAINIPPON SOCHUGIKU KABUSHIKI KAISHA (JP) 1984-07-10 US claimed
US-4031235-A Insecticidal substituted acetate compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-21 US claimed
JP-54067030-A None JP disclosed
JP-52127996-A None JP disclosed
US-20230220132-A1 FAST PHOTOCURABLE POLYCYCLOOLEFIN COMPOSITIONS AS OPTICAL OR 3D PRINTING MATERIALS PROMERUS, LLC (US) 2023-07-13 US disclosed
US-4039680-A SULFUR CONTAINING HETEROCYCLES SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-08-02 US disclosed
US-4031235-A Insecticidal substituted acetate compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-06-21 US disclosed
US-3996244-A Insecticidal esters of substituted furan methanol SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1976-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269869-A1 PRODUCTION OF OPHTHALMIC DEVICES BASED ON PHOTO-INDUCED STEP GROWTH POLYMERIZATION CRYAA, CRYZ, CRYAB CASP3 3488/4885POLB 956/4885ALDH1A1 2409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.