Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Menadione Sulfurous Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 1.00 |
| ▸ | PKLR known ✓ | P30613 | 2/20 | 0.34 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | PARG | Q86W56 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menadione Sulfurous Acid SCHEMBL461612 | 1.00 | MEN1 (1.00) | MEN1KMT2APOLBPARGPKLR | |
| Menadione Sulfurous Acid SCHEMBL29364956 | 1.00 | MEN1 (1.00) | MEN1KMT2APOLBPARGPKLR | |
| Menadione Sulfurous Acid SCHEMBL435171 | 0.98 | MEN1 (0.97) | MEN1KMT2APOLBPARGPKLR | |
| Menadione Sulfurous Acid SCHEMBL29973176 | 0.98 | MEN1 (0.97) | MEN1KMT2APOLBPARGPKLR | |
| Menadione Sulfurous Acid SCHEMBL459906 | 0.95 | MEN1 (0.91) | MEN1KMT2APOLBPARGPKLR | |
| Menadione Sulfurous Acid SCHEMBL461201 | 0.95 | MEN1 (0.91) | MEN1KMT2APOLBPARGPKLR | |
| SCHEMBL18309831 | 0.81 | MEN1 (0.69) | MEN1KMT2APOLBPARGALDH1A1 | |
| Menadione Sulfurous Acid SCHEMBL461613 | 0.81 | POLB (0.68) | MEN1KMT2APOLBPARGALDH1A1 | |
| Menadione Sulfurous Acid SCHEMBL460404 | 0.81 | POLB (0.68) | MEN1KMT2APOLBPARGALDH1A1 | |
| Menadione Sulfurous Acid SCHEMBL459525 | 0.80 | POLB (0.67) | MEN1KMT2APOLBPARGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111254109-B | Method for in vitro fertilization and embryo culture of bovine oocytes and transport culture solution | 天津力牧生物科技有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-113201484-B | Method for improving cryopreservation and thawing of bovine in vitro fertilization blastocysts | 天津力牧生物科技有限公司 | 2022-05-27 | — | — | CN | claimed |
| CN-112501114-B | Method for improving cattle in-vitro fertilization efficiency | 天津力牧生物科技有限公司 | 2022-05-27 | — | — | CN | claimed |
| CN-113151160-B | Method for improving cattle in-vitro fertilization efficiency and used freezing medium and thawing medium | 天津力牧生物科技有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-108728401-B | Method for culturing bovine oocyte in vitro fertilization embryo and used culture medium | 天津博裕力牧科技有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-108728404-B | Method for culturing in vitro fertilization embryo of bovine living body or in vitro collected oocyte | 天津博裕力牧科技有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-108753689-B | Method for culturing bovine in-vitro fertilized embryo | 天津博裕力牧科技有限公司 | 2021-09-07 | — | — | CN | claimed |
| CN-113201484-A | Method for improving cryopreservation and thawing of bovine in vitro fertilization blastocysts | 天津博裕力牧科技有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-112980778-B | Method for culturing and cryopreserving bovine in-vitro fertilization embryos | 天津博裕力牧科技有限公司 | 2021-07-30 | — | — | CN | claimed |
| CN-113151160-A | Method for improving cattle in-vitro fertilization efficiency and used freezing medium and thawing medium | 天津博裕力牧科技有限公司 | 2021-07-23 | — | — | CN | claimed |
| CN-112980778-A | Method for culturing and cryopreserving bovine in-vitro fertilization embryos | 天津博裕力牧科技有限公司 | 2021-06-18 | — | — | CN | claimed |
| CN-112501114-A | Method for improving cattle in-vitro fertilization efficiency | 天津博裕力牧科技有限公司 | 2021-03-16 | — | — | CN | claimed |
| CN-112322579-B | Culture solution for cattle in-vitro fertilization and method for improving cattle in-vitro fertilization | 天津博裕力牧科技有限公司 | 2021-03-12 | — | — | CN | claimed |
| CN-112322579-A | Culture solution for cattle in-vitro fertilization and method for improving cattle in-vitro fertilization | 天津博裕力牧科技有限公司 | 2021-02-05 | — | — | CN | claimed |
| EP-2629765-B1 | METHODS AND COMPOSITIONS FOR TREATING POX VIRUS INFECTIONS WITH AN 1,4-NAPHTHOQUINONE AS ACTIVE AGENT | HÜGIN AMBROS (CH) | 2016-07-06 | — | — | EP | claimed |
| US-20130224286-A1 | METHODS AND COMPOSITIONS FOR TREATING POX VIRUS INFECTIONS | HUEGIN AMBROS (CH) | 2013-08-29 | — | — | US | claimed |
| EP-2629765-A1 | METHODS AND COMPOSITIONS FOR TREATING POX VIRUS INFECTIONS WITH AN 1, 4 -NAPHTHOQUINONE AS ACTIVE AGENT | Hügin, Ambros (CH) | 2013-08-28 | — | — | EP | claimed |
| WO-2012052956-A1 | METHODS AND COMPOSITIONS FOR TREATING POX VIRUS INFECTIONS WITH AN 1, 4 -NAPHTHOQUINONE AS ACTIVE AGENT | HUEGIN AMBROS (CH) | 2012-04-26 | — | — | WO | claimed |
| US-12295957-B2 | Ascorbic acid and quinone compounds in combination with an antiparasitic agent for treating a parasitic disease | IC-MedTech Corp. (US) | 2025-05-13 | — | — | US | disclosed |
| WO-2011011317-A1 | VITAMIN C AND VITAMIN K, AND COMPOSITIONS THEREOF FOR TREATMENT OF OSTEOLYSIS OR PROLONGATION OF PROSTHETIC IMPLANT | SUMMA HEALTH SYSTEM (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12295957-B2 | Ascorbic acid and quinone compounds in combination with an antiparasitic agent for treating a parasitic disease | NQO1, ADH7, CYP27B1 | MEN1 2407/4885PKLR 3100/4885THRB 3967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.