Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RORA | P35398 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618976 | 0.87 | PKM (0.56) | FFAR4HTR6MAPTL3MBTL1GAA | |
| SCHEMBL8174103 | 0.82 | GAA (0.52) | FFAR4HTR6LMNAMAPTGAA | |
| SCHEMBL4616809 | 0.82 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8FFAR4 | |
| SCHEMBL4618091 | 0.81 | FFAR4 (0.49) | FFAR4HTR6LMNAMAPTGAA | |
| SCHEMBL4618632 | 0.81 | ABCC9 (0.47) | ABCC9ABCC8KCNJ11KCNJ8HTR6 | |
| SCHEMBL4617109 | 0.79 | HSD11B1 (0.52) | ABCC9ABCC8KCNJ11KCNJ8FFAR4 | |
| SCHEMBL3151230 | 0.79 | MTNR1B (0.56) | ABCC9ABCC8KCNJ11KCNJ8FFAR4 | |
| SCHEMBL31352975 | 0.79 | MTNR1B (0.56) | ABCC9ABCC8KCNJ11KCNJ8FFAR4 | |
| SCHEMBL8865965 | 0.78 | LMNA (0.56) | ABCC9ABCC8KCNJ11KCNJ8FFAR4 | |
| SCHEMBL28311554 | 0.78 | HSD11B1 (0.50) | ABCC9ABCC8KCNJ11KCNJ8HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ABCC9 872/4885ABCC8 1824/4885KCNJ11 2716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.