SCHEMBL4626004

SCHEMBL4626004

N[C@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.47
▸ CYP2C9 P11712 3/20 0.47
▸ MEN1 O00255 3/20 0.47
▸ KMT2A Q03164 3/20 0.47
▸ BLM P54132 3/20 0.47
▸ USP2 O75604 2/20 0.47
▸ PKM P14618 2/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ KDM4E B2RXH2 2/20 0.47
▸ RGS12 O14924 1/20 0.47
▸ CYP3A4 P08684 1/20 0.47
▸ ALOX15 P16050 1/20 0.47
▸ NFKB1 P19838 1/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ BRCA1 P38398 1/20 0.47
▸ THPO P40225 1/20 0.47
▸ CASP7 P55210 1/20 0.47
▸ GNAI1 P63096 1/20 0.47
▸ HIF1A Q16665 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL158168 1.00 MAPT (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL43843 1.00 MAPT (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5324038 0.90 USP2 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5283079 0.90 USP2 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5282915 0.88 USP2 (0.46) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL2971633 0.88 GRIA1 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL2971635 0.88 GRIA1 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL23682935 0.86 GRIA1 (0.46) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL13205282 0.85 TSHR (0.42) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5285947 0.84 USP2 (0.50) MAPTCYP2C9MEN1KMT2ABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9896481-B2 Modified mini-hepcidin peptides and methods of using thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-02-20 — — US claimed
US-20160022636-A1 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2016-01-28 — — US claimed
EP-2968240-A2 PHYSIOLOGICAL LIGANDS FOR GPR139 Janssen Pharmaceutica, N.V. (BE) 2016-01-20 — — EP claimed
US-20140336216-A1 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2014-11-13 — — US claimed
WO-2014152917-A2 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 — — WO claimed
EP-4731268-A1 CROSS-LINKED VESICLES WITH LOW-BOILING POINT FLUORINATED COMPOUND Bracco Suisse SA (CH) 2026-04-29 — — EP disclosed
US-20260014283-A1 ULTRASOUND-SENSITIVE PEPTIDE PARTICLES FOR SPATIALLY RESOLVED MOLECULE DELIVERY AND METHODS OF USING THE SAME PENN STATE RES FOUND (US) 2026-01-15 — — US disclosed
EP-4637837-A1 CATIONIC CROSS-LINKED VESICLES Bracco Suisse SA (CH) 2025-10-29 — — EP disclosed
WO-2025090926-A1 ULTRASOUND-SENSITIVE PEPTIDE PARTICLES WITH SURFACE-BOUND GENE EDITING TOOLS FOR SPATIALLY RESOLVED MOLECULE DELIVERY THE PENN STATE RESEARCH FOUNDATION (US) 2025-05-01 — — WO disclosed
US-20250032619-A1 MICROFLUIDIC PREPARATION OF FLUOROCARBON CROSS-LINKED VESICLES BRACCO SUISSE SA (CH) 2025-01-30 — — US disclosed
WO-2024261165-A1 CROSS-LINKED VESICLES WITH LOW-BOILING POINT FLUORINATED COMPOUND BRACCO SUISSE SA (CH) 2024-12-26 — — WO disclosed
US-20240358640-A1 ULTRASOUND-SENSITIVE PEPTIDE PARTICLES FOR SPATIALLY RESOLVED MOLECULE DELIVERY THE PENN STATE RESEARCH FOUNDATION 2024-10-31 — — US disclosed
US-20160022636-A1 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2016-01-28 — — US disclosed
EP-2968240-A2 PHYSIOLOGICAL LIGANDS FOR GPR139 Janssen Pharmaceutica, N.V. (BE) 2016-01-20 — — EP disclosed
US-20140336216-A1 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2014-11-13 — — US disclosed
WO-2014152917-A2 PHYSIOLOGICAL LIGANDS FOR GPR139 JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 — — WO disclosed
EP-1078002-B1 PEPTIDE ANTIANGIOGENIC DRUGS ABBOTT LAB (US) 2008-05-21 — — EP disclosed
US-20050124548-A1 Peptide antiangiogenic drugs HENKIN JACK (US) 2005-06-09 — — US disclosed
US-6774211-B1 Peptide antiangiogenic drugs ABBOTT LABORATORIES 2004-08-10 — — US disclosed
US-6716963-B1 OLIGOPEPTIDES ABBOTT LABORATORIES 2004-04-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250032619-A1 MICROFLUIDIC PREPARATION OF FLUOROCARBON CROSS-LINKED VESICLES EXOSC9, CHMP4B, EXOSC5 MAPT 2507/4885CYP2C9 2809/4885MEN1 3459/4885
US-20050124548-A1 Peptide antiangiogenic drugs VEGFA, NPPA, FLT1 MAPT 4603/4885CYP2C9 3361/4885MEN1 646/4885
US-20260014283-A1 ULTRASOUND-SENSITIVE PEPTIDE PARTICLES FOR SPATIALLY RESOLVED MOLECULE DELIVERY AND METHODS OF USING THE SAME HDGFL3, HDGF, HM13 MAPT 1797/4885CYP2C9 4498/4885MEN1 2051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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