SCHEMBL158168

SCHEMBL158168

N[C@@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.47
CYP2C9 P11712 3/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
BLM P54132 3/20 0.47
USP2 O75604 2/20 0.47
PKM P14618 2/20 0.47
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 2/20 0.47
RGS12 O14924 1/20 0.47
CYP3A4 P08684 1/20 0.47
ALOX15 P16050 1/20 0.47
NFKB1 P19838 1/20 0.47
CASP1 P29466 1/20 0.47
BRCA1 P38398 1/20 0.47
THPO P40225 1/20 0.47
CASP7 P55210 1/20 0.47
GNAI1 P63096 1/20 0.47
HIF1A Q16665 1/20 0.47
HSD17B10 Q99714 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL43843 1.00 MAPT (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL4626004 1.00 MAPT (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5324038 0.90 USP2 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5283079 0.90 USP2 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL2971633 0.88 GRIA1 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL2971635 0.88 GRIA1 (0.47) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5282915 0.88 USP2 (0.46) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL23682935 0.86 GRIA1 (0.46) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL13205282 0.85 TSHR (0.42) MAPTCYP2C9MEN1KMT2ABLM
SCHEMBL5285947 0.84 USP2 (0.50) MAPTCYP2C9MEN1KMT2ABLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 600 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590123-B2 Compounds and methods for treating cancer, viral infections, and allergic conditions WASHINGTON UNIVERSITY (US) 2026-03-31 US claimed
EP-4127157-B1 MODIFIED DIPEPTIDE CLEAVASES, USES THEREOF AND RELATED KITS ENCODIA INC (US) 2026-02-11 EP claimed
US-12486304-B2 Peptide ligand targeting carbonic anhydrase IX, peptide construct comprising same, and uses thereof C-BIOMEX CO., LTD. (KR) 2025-12-02 US claimed
US-12428447-B2 Peptide-based non-proteinaceous cargo delivery FELDAN BIO INC. (CA) 2025-09-30 US claimed
US-20250179465-A1 SITE-SPECIFIC ENCODING OF FLUORINATED PHENYLALANINE RESIDUES IN BACTERIAL AND MAMMALIAN CELLS UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2025-06-05 US claimed
US-20250171495-A1 MUTLI-TARGETED SERINE PROTEASE INHIBITORS FOR TREATMENT OF CANCER AND VIRAL INFECTION WASHINGTON UNIVERSITY 2025-05-29 US claimed
CN-117120458-B Peptide ligands targeting carbonic anhydrase IX, peptide structures comprising the same, and uses thereof C-比奥麦克斯有限公司 2025-04-04 CN claimed
EP-4522221-A1 COMPOSITIONS AND METHODS FOR DELIVERY OF NUCLEIC ACID THERAPEUTICS Entrada Therapeutics, Inc. (US) 2025-03-19 EP claimed
EP-4479526-A1 SITE-SPECIFIC ENCODING OF FLUORINATED PHENYLALANINE RESIDUES IN BACTERIAL AND MAMMALIAN CELLS University of Iowa Research Foundation (US) 2024-12-25 EP claimed
US-20240327464-A1 PEPTIDE LIGAND TARGETING CARBONIC ANHYDRASE IX, PEPTIDE CONSTRUCT COMPRISING SAME, AND USES THEREOF C-BIOMEX CO., LTD. (KR) 2024-10-03 US claimed
US-8486370-B2 Heterocyclic ligands for integrin imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-07-16 US claimed
US-8435941-B2 Mini-hepcidin peptides and methods of using thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-05-07 US claimed
EP-1962959-B1 NEUROPEPTIDE-2 RECEPTOR-AGONISTS HOFFMANN LA ROCHE (CH) 2012-03-14 EP claimed
EP-1844070-B1 PEPTIDES WITH NEUROPEPTIDE-2 RECEPTOR (Y2R) AGONIST ACTIVITY HOFFMANN LA ROCHE (CH) 2011-03-02 EP claimed
US-20100310455-A1 Heterocyclic Ligands for Integrin Imaging and Therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2010-12-09 US claimed
US-7576175-B2 Amino acid terminated diphenylurea derivatives; display high binding affinity, specificity, and stability; use in treating cancer, inflammatory diseases, and autoimmune diseases THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-08-18 US claimed
WO-2008031016-A2 HETEROCYCLIC LIGANDS FOR INTEGRIN IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2008-03-13 WO claimed
WO-2005122379-A9 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY UNIV CALIFORNIA (US) 2006-03-09 WO claimed
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-01-26 US claimed
WO-2005122379-A2 ALPHA-4 BETA-1 INTEGRIN LIGANDS FOR IMAGING AND THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-12-22 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100310455-A1 Heterocyclic Ligands for Integrin Imaging and Therapy ITGA1, ITGAL, ITGA4 MAPT 4088/4885CYP2C9 4551/4885MEN1 1052/4885
US-12590123-B2 Compounds and methods for treating cancer, viral infections, and allergic conditions TMPRSS2, TMPRSS4, F2RL3 MAPT 3390/4885CYP2C9 3134/4885MEN1 3039/4885
US-12486304-B2 Peptide ligand targeting carbonic anhydrase IX, peptide construct comprising same, and uses thereof CA9, CA4, CA12 MAPT 4177/4885CYP2C9 2581/4885MEN1 1422/4885
US-20250171495-A1 MUTLI-TARGETED SERINE PROTEASE INHIBITORS FOR TREATMENT OF CANCER AND VIRAL INFECTION TMPRSS2, PRSS1, PRSS2 MAPT 2599/4885CYP2C9 2575/4885MEN1 358/4885
US-20060019900-A1 Alpha-4 beta-1 integrin ligands for imaging and therapy ITGA4, ITGB4, ITGA1 MAPT 3133/4885CYP2C9 4786/4885MEN1 892/4885
US-20240327464-A1 PEPTIDE LIGAND TARGETING CARBONIC ANHYDRASE IX, PEPTIDE CONSTRUCT COMPRISING SAME, AND USES THEREOF CA9, CA4, CA12 MAPT 4177/4885CYP2C9 2581/4885MEN1 1422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.