Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 9/20 | 0.41 |
| ▸ | HTR7 | P34969 | 9/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15614423 | 0.90 | L3MBTL1 (0.51) | DRD2HTR6MAPTALDH1A1L3MBTL1 | |
| SCHEMBL16849228 | 0.84 | BRD4 (0.49) | DRD2HTR6BRD4HTR1AHTR7 | |
| SCHEMBL4734388 | 0.83 | CCR8 (0.46) | DRD2HTR6MAPTALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL4734829 | 0.82 | CCR8 (0.46) | DRD2HTR6MAPTALDH1A1L3MBTL1 | |
| SCHEMBL4616096 | 0.81 | SFRP1 (0.49) | ALDH1A1L3MBTL1 | |
| SCHEMBL4618843 | 0.81 | ALDH1A1 (0.39) | DRD2HTR6ALDH1A1L3MBTL1MEN1 | |
| SCHEMBL4727780 | 0.81 | CTSL (0.40) | DRD2HTR6MAPTALDH1A1L3MBTL1 | |
| SCHEMBL13162704 | 0.81 | PKM (0.51) | MAPTALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL6101380 | 0.80 | HTR1A (0.41) | DRD2HTR6MAPTALDH1A1BRD4 | |
| SCHEMBL4782205 | 0.79 | CA1 (0.50) | DRD2HTR6MAPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | DRD2 4401/4885HTR6 3789/4885MAPT 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.