Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.52 |
| ▸ | CA1 | P00915 | 16/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4642785 | 0.96 | CA2 (0.55) | CA2CA1CA4THRATHRB | |
| SCHEMBL1598468 | 0.80 | ALDH1A1 (0.52) | MAPTTHRBEPHX2 | |
| SCHEMBL4642781 | 0.78 | SRD5A2 (0.50) | MAPTTHRBEPHX2 | |
| SCHEMBL4643451 | 0.78 | SRD5A2 (0.50) | MAPTTHRBEPHX2 | |
| Terephthalic Acid SCHEMBL31095057 | 0.73 | CA2 (0.68) | CA2CA1CA4MAPT | |
| Terephthalic Acid SCHEMBL107909 | 0.73 | CA2 (0.68) | CA2CA1CA4MAPT | |
| Potassium Ion SCHEMBL6911291 | 0.71 | ALDH1A1 (0.61) | CA2CA1MAPT | |
| SCHEMBL6909054 | 0.71 | ALDH1A1 (0.61) | CA2CA1MAPT | |
| Potassium Ion SCHEMBL8023908 | 0.71 | CA2 (0.95) | CA2CA1CA4MAPT | |
| Potassium Ion SCHEMBL5888927 | 0.71 | HDAC1 (0.57) | CA2CA1MAPTEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1120391-B1 | MOLECULAR COMPOUNDS CONTAINING NOVEL CARBOXYLIC ACID DERIVATIVES AS THE CONSTITUENT COMPOUND | NIPPON SODA CO (JP) | 2008-08-06 | — | — | EP | disclosed |
| US-6566548-B1 | Alkylene- or phenylene- tetrabenzoic acids and derivatives | NIPPON SODA CO., LTD. (JP) | 2003-05-20 | — | — | US | disclosed |
| EP-1120391-A1 | MOLECULAR COMPOUNDS CONTAINING NOVEL CARBOXYLIC ACID DERIVATIVES AS THE CONSTITUENT COMPOUND | NIPPON SODA CO., LTD. (JP) | 2001-08-01 | — | — | EP | disclosed |