Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1691497 | 0.95 | SMN1; SMN2 (0.54) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL11142367 | 0.84 | ALDH1A1 (0.74) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL14618810 | 0.83 | ALDH1A1 (0.51) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL13498455 | 0.83 | ALDH1A1 (0.51) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL13973749 | 0.82 | ALDH1A1 (0.54) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL3824793 | 0.82 | ALDH1A1 (0.57) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL13547897 | 0.80 | ALDH1A1 (0.57) | TP53ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL29930151 | 0.79 | ALDH1A1 (0.62) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL171739 | 0.79 | ALDH1A1 (0.62) | TP53ALDH1A1HPGDAKR1C3SMN1; SMN2 | |
| SCHEMBL1773906 | 0.79 | TP53 (0.41) | TP53ALDH1A1HPGDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-11-23 | — | — | US | disclosed |
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (CN) | 2023-11-23 | — | — | US | disclosed |
| US-20230054997-A1 | COPPER COMPLEXES FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | ALS THERAPY DEVELOPMENT INSTITUTE, | 2023-02-23 | — | — | US | disclosed |
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | CELGENE CAR LLC (BM) | 2022-06-07 | — | — | US | disclosed |
| US-10828300-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE CAR LLC (BM) | 2020-11-10 | — | — | US | disclosed |
| US-10752624-B2 | Kinase inhibitors | ORIGENIS GMBH (DE) | 2020-08-25 | — | — | US | disclosed |
| US-20200231588-A1 | Bicyclic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. | 2020-07-23 | — | — | US | disclosed |
| US-20200123165-A1 | KINASE INHIBITORS | INSILICO MEDICINE LTD. (CN) | 2020-04-23 | — | — | US | disclosed |
| US-10596172-B2 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | CELGENE CAR LLC (BM) | 2020-03-24 | — | — | US | disclosed |
| US-20190192512-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2019-06-27 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| EP-1753745-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | Pfizer Products Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| CN-1745049-A | Ligands for metals and improved metal-catalyzed processes based thereon | MASSACHUSETTS INST TECHNOLOGY (US) | 2006-03-08 | — | — | CN | disclosed |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | PFIZER INC | 2005-12-22 | — | — | US | disclosed |
| WO-2005113535-A2 | PYRAZINYLMETHYL LACTAM DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2005-12-01 | — | — | WO | disclosed |
| EP-1581467-A2 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | NATIONAL SCIENCE FOUNDATION | 2004-09-02 | — | — | US | disclosed |
| WO-2004052939-A2 | LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2004-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | DCK, CDK2, DTYMK | TP53 486/4885ALDH1A1 2583/4885HPGD 2962/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | TP53 1979/4885ALDH1A1 3939/4885HPGD 2424/4885 |
| US-20190192512-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | TP53 1214/4885ALDH1A1 684/4885HPGD 1580/4885 |
| US-20050282816-A1 | Pyrazinylmethyl lactam derivatives | HTR1A, HTR1D, HTR1B | TP53 4738/4885ALDH1A1 449/4885HPGD 1602/4885 |
| US-20230054997-A1 | COPPER COMPLEXES FOR TREATMENT OF NEURODEGENERATIVE DISORDERS | SOD1, SMN1; SMN2, CLN6 | TP53 2417/4885ALDH1A1 1721/4885HPGD 2845/4885 |
| US-20200231588-A1 | Bicyclic Heteroaryl Compounds | CYP3A43, CYP11B2, CYP2F1 | TP53 3009/4885ALDH1A1 636/4885HPGD 1280/4885 |
| US-20040171833-A1 | Ligands for metals and improved metal-catalyzed processes based thereon | THEM6, SLC30A6, SOD1 | TP53 1752/4885ALDH1A1 1766/4885HPGD 1487/4885 |
| US-10828300-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | ABL1, DCK, ERBB2 | TP53 436/4885ALDH1A1 1989/4885HPGD 2867/4885 |
| US-20230373972-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | F7, F11, HABP2 | TP53 3186/4885ALDH1A1 1218/4885HPGD 458/4885 |
| US-20070105852-A1 | Thiophene and furan compounds | PSEN2, PSEN1, TPMT | TP53 147/4885ALDH1A1 1344/4885HPGD 2788/4885 |
| US-10752624-B2 | Kinase inhibitors | LRRK2, MYLK2, MYLK | TP53 2073/4885ALDH1A1 4184/4885HPGD 4156/4885 |
| US-10596172-B2 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | DCK, CDK2, DTYMK | TP53 486/4885ALDH1A1 2583/4885HPGD 2962/4885 |
| US-20200123165-A1 | KINASE INHIBITORS | DDR1, DDR2, DDRGK1 | TP53 1208/4885ALDH1A1 4080/4885HPGD 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.