SCHEMBL4649512

SCHEMBL4649512

CCS(=O)(=O)Nc1cccc2ccc(O)cc12

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 17/20 0.50
KDM4E B2RXH2 1/20 0.48
MEN1 O00255 1/20 0.48
MAPT P10636 1/20 0.48
RAB9A P51151 1/20 0.48
KMT2A Q03164 1/20 0.48
MTNR1A P48039 1/20 0.48
MTNR1B P49286 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11694405 0.85 TRPV1 (0.51) TRPV1MEN1MAPTKMT2A
SCHEMBL9351736 0.84 KEAP1 (0.65) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL11019096 0.82 TRPV1 (0.49) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL1413142 0.81 MCL1 (0.50) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL2128507 0.80 KEAP1 (0.68) KDM4EMEN1MAPTKMT2A
SCHEMBL16187950 0.80 MEN1 (0.58) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL6583801 0.79 TRPV1 (0.54) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL9816152 0.78 ADRA1A (0.55) TRPV1KDM4EMEN1MAPTRAB9A
SCHEMBL808090 0.77 HKDC1 (0.61) TRPV1MEN1MAPTKMT2A
SCHEMBL8021152 0.76 TRPV1 (0.61) TRPV1KDM4EMEN1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1961738-A1 New compounds with antiglutamatergic properties and uses thereof Faust Pharmaceuticals (FR) 2008-08-27 EP disclosed
EP-1961738-A1 New compounds with antiglutamatergic properties and uses thereof Faust Pharmaceuticals (FR) 2008-08-27 EP disclosed
WO-2008098751-A1 NEW COMPOUNDS WITH ANTIGLUTAMATERGIC PROPERTIES AND USES THEREOF FAUST PHARMACEUTICALS (FR) 2008-08-21 WO disclosed
WO-2008098751-A1 NEW COMPOUNDS WITH ANTIGLUTAMATERGIC PROPERTIES AND USES THEREOF FAUST PHARMACEUTICALS (FR) 2008-08-21 WO disclosed
EP-0158098-B1 MIXTURES OF 1:2 CHROMIUM COMPLEX DYES BAYER AG (DE) 1987-12-23 EP disclosed
EP-0158098-A2 Mixtures of 1:2 chromium complex dyes BAYER AG (DE) 1985-10-16 EP disclosed
EP-0066230-A1 1:2-asymmetric dyestuffs of chromium BAYER AG (DE) 1982-12-08 EP disclosed
US-4219473-A Substituted unsymmetrical azo, azomethine 1:2 chromium complexes CIBA-GEIGY CORPORATION (US) 1980-08-26 US disclosed
US-4053462-A UNSYMMETRICAL PHENYL AZO NAPHTHYL CHROMIUM COMPLEX DYES CIBA-GEIGY CORPORATION (US) 1977-10-11 US disclosed
US-4005065-A GOOD FASTNESS TO LIGHT, PERSPIRATION, FULLING, DECATIZING AND CARBONIZING CIBA-GEIGY CORPORATION (US) 1977-01-25 US disclosed