Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 10/20 | 0.54 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152712 | 0.83 | HTR1B (0.56) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL11278399 | 0.83 | HTR1B (0.56) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL5289923 | 0.81 | HTR1B (0.77) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL5637449 | 0.79 | HTR1B (0.48) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL28119137 | 0.78 | KMT2A (0.46) | HTR1BKCNA3MEN1KMT2AKDM4E | |
| Methane SCHEMBL27611186 | 0.76 | KMT2A (0.45) | HTR1BKCNA3MEN1KMT2AKDM4E | |
| Sulfuric Acid SCHEMBL2471561 | 0.76 | HTR1B (0.56) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL8642238 | 0.76 | HTR1B (0.69) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL8674828 | 0.76 | HTR1B (0.69) | HTR1BKCNA3MEN1KMT2AHTR1D | |
| SCHEMBL2177350 | 0.75 | HTR1B (0.78) | HTR1BKCNA3KMT2AHTR1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1571493-B1 | Polymerizable composition and lithographic printing plate precursor | FUJIFILM CORP (JP) | 2015-09-09 | — | — | EP | disclosed |
| EP-1703330-B1 | Plate-making method of negative-working lithographic printing plate precursor | FUJIFILM CORP (JP) | 2008-11-19 | — | — | EP | disclosed |
| EP-1571493-A1 | Polymerizable composition and lithographic printing plate precursor | FUJI PHOTO FILM CO., LTD. (JP) | 2005-09-07 | — | — | EP | disclosed |
| EP-1211096-A1 | Base material for lithographic printing plate and lithographic printing plate using the same | FUJI PHOTO FILM CO., LTD. (JP) | 2002-06-05 | — | — | EP | disclosed |