Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.36 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.36 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.36 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.36 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.36 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.36 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657183 | 0.88 | CTSL (0.47) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL4656418 | 0.88 | APP (0.43) | APPATMCTSKSYK | |
| SCHEMBL4657115 | 0.84 | ATM (0.51) | APPATMNPC1RAB9ACTSL | |
| SCHEMBL4656232 | 0.79 | OPRK1 (0.42) | FNTAFNTB | |
| SCHEMBL13979534 | 0.79 | OPRK1 (0.42) | FNTAFNTB | |
| SCHEMBL4656413 | 0.79 | SYK (0.51) | APPATMCTSLCTSKSYK | |
| SCHEMBL4657113 | 0.74 | SYK (0.60) | APPATMCTSLCTSKSYK | |
| SCHEMBL3987635 | 0.74 | CA2 (0.38) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL3989377 | 0.72 | CA2 (0.39) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL3989366 | 0.71 | MAPK1 (0.36) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006122-B1 | PHENETHYLAMINE DERIVATIVES | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2008-12-03 | — | — | EP | disclosed |
| US-6255285-B1 | GASTROINTESTINAL DISORDERS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2001-07-03 | — | — | US | disclosed |
| EP-1006122-A1 | PHENETHYLAMINE DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2000-06-07 | — | — | EP | disclosed |