Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048447 | 0.85 | EGLN1 (0.41) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL27789732 | 0.79 | GRIK1 (0.38) | GAAALDH1A1LMNAGRIK1ALOX15 | |
| SCHEMBL28052037 | 0.77 | FAAH (0.37) | ALDH1A1LMNAGRIK1ALOX15KDM4E | |
| SCHEMBL12640922 | 0.75 | GRIK1 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL6551852 | 0.75 | GRIK1 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL14598192 | 0.75 | GRIK1 (0.40) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL3179017 | 0.74 | MAPT (0.38) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL13269286 | 0.74 | ALDH1A1 (0.39) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL7041913 | 0.73 | GLO1 (0.39) | MGAMGAASIMGAM2ALDH1A1 | |
| SCHEMBL13783789 | 0.73 | MGAM (0.38) | MGAMGAASIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392638-B1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | BASELL POLIOLEFINE ITALIA SRL (IT) | 2016-12-14 | — | — | EP | disclosed |
| EP-1527039-B1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASELL POLIOLEFINE SRL (IT) | 2008-12-24 | — | — | EP | disclosed |
| US-7465821-B2 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2008-12-16 | — | — | US | disclosed |
| US-7399879-B2 | Process for preparing alkylidene-substituted-1,4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2008-07-15 | — | — | US | disclosed |
| US-6914153-B2 | Process for preparing alkylidene substituted succinic acid esters | BASSELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-07-05 | — | — | US | disclosed |
| US-20050113599-A1 | Process for preparing alkylidene-substituted -1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-05-26 | — | — | US | disclosed |
| EP-1527039-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | Basell Poliolefine Italia S.P.A. (IT) | 2005-05-04 | — | — | EP | disclosed |
| EP-1527040-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | Basel Poliolefine Italia SpA (IT) | 2005-05-04 | — | — | EP | disclosed |
| US-20050080290-A1 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2005-04-14 | — | — | US | disclosed |
| EP-1392638-A1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | Basell Poliolefine Italia S.p.A. (IT) | 2004-03-03 | — | — | EP | disclosed |
| WO-2004014838-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-02-19 | — | — | WO | disclosed |
| WO-2004014839-A1 | PROCESS FOR PREPARING ALKYLIDENE-SUBSTITUTED-1,4-DIONS DERIVATIVES | BASEL POLIOLEFINE ITALIA S.P.A. (IT) | 2004-02-19 | — | — | WO | disclosed |
| US-20030181743-A1 | Process for preparing alkylidene substituted succinic acid esters | BASELL POLIOLEFINE ITALIA S.P.A. (IT) | 2003-09-25 | — | — | US | disclosed |
| WO-2002098837-A1 | PROCESS FOR PREPARING ALKYLIDENE SUBSTITUTED SUCCINIC ACID ESTERS | BASELL POLIOLEFINE ITALIA S.P.A (IT) | 2002-12-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113599-A1 | Process for preparing alkylidene-substituted -1, 4-dions derivatives | KCNJ4, NR3C2, NR4A2 | MGAM 3919/4885GAA 4586/4885SI 3511/4885 |
| US-20030181743-A1 | Process for preparing alkylidene substituted succinic acid esters | OGDH, SCO2, SUCNR1 | MGAM 776/4885GAA 3356/4885SI 32/4885 |
| US-20050080290-A1 | Process for preparing alkylidene-substituted-1, 4-dions derivatives | RTN4, NR4A2, NR3C2 | MGAM 4851/4885GAA 4844/4885SI 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.