SCHEMBL4671925

SCHEMBL4671925

COc1cc(/C=C/C(=O)Nc2ccc(O)cc2C(=O)O)ccc1O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 6/20 0.69
MEN1 O00255 4/20 0.65
KMT2A Q03164 4/20 0.65
ALDH1A1 P00352 3/20 0.65
TP53 P04637 3/20 0.65
CYP3A4 P08684 3/20 0.65
HPGD P15428 3/20 0.65
HIF1A Q16665 3/20 0.65
NFKB1 P19838 3/20 0.65
KDM4E B2RXH2 3/20 0.65
PKM P14618 3/20 0.65
CYP2C9 P11712 3/20 0.65
HSD17B10 Q99714 3/20 0.65
CYP1A2 P05177 2/20 0.65
CYP2C19 P33261 2/20 0.65
ALOX12 P18054 2/20 0.65
MAPK1 P28482 2/20 0.65
PTGS2 P35354 2/20 0.65
NPSR1 Q6W5P4 2/20 0.65
NPC1 O15118 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30087650 1.00 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL23630641 1.00 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL29375351 1.00 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL6013366 1.00 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL30087639 1.00 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL9973848 0.92 KDM1A (0.67) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL4669878 0.92 MEN1 (0.77) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL8640599 0.92 MEN1 (0.77) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL9973830 0.91 MEN1 (0.65) KDM1AMEN1KMT2AALDH1A1TP53
SCHEMBL35210122 0.89 KDM1A (0.69) KDM1AMEN1KMT2AALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006117602-A2 USE OF AMIDE DERIVATIVES AS TASTE-MODIFYING AGENTS, FLAVOURING COMPOSITIONS AND PRODUCTS CONTAINING THEM UNIVERSITA' DEGLI STUDI DI MILANO (IT) 2006-11-09 WO claimed
US-12564551-B2 Composition or oat extract comprising avenanthramide and β-glucan SYMRISE AG (DE) 2026-03-03 US disclosed
EP-4487838-A2 AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE Symrise AG (DE) 2025-01-08 EP disclosed
EP-4114354-B1 AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE SYMRISE AG (DE) 2024-12-11 EP disclosed
WO-2024020099-A1 METHOD FOR INCREASING THE CONCENTRATION OF ONE OR MORE BIO-ACTIVES IN GRAINS THE QUAKER OATS COMPANY (US) 2024-01-25 WO disclosed
US-20240023476-A1 Method for Increasing the Concentration of one or more Bio-actives in Grains THE QUAKER OATS COMPANY 2024-01-25 US disclosed
US-20230131993-A1 COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY SYMRISE AG (DE) 2023-04-27 US disclosed
US-20230131993-A1 COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY SYMRISE AG (DE) 2023-04-27 US disclosed
US-20230129036-A1 AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE SYMRISE AG (DE) 2023-04-27 US disclosed
US-20230131993-A1 COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY SYMRISE AG (DE) 2023-04-27 US disclosed
US-20090226537-A1 MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING SYMRISE GMBH & CO. KG (DE) 2009-09-10 US disclosed
US-20090226537-A1 MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING SYMRISE GMBH & CO. KG (DE) 2009-09-10 US disclosed
EP-1886662-A1 Anti-microbial compounds for treating bad breath Symrise GmbH & Co. KG (DE) 2008-02-13 EP disclosed
EP-1886662-A1 Anti-microbial compounds for treating bad breath Symrise GmbH & Co. KG (DE) 2008-02-13 EP disclosed
US-20080008660-A1 Antimicrobially active compounds for treating bad breath SYMRISE GMBH & CO. KG (DE) 2008-01-10 US disclosed
US-20080008660-A1 Antimicrobially active compounds for treating bad breath SYMRISE GMBH & CO. KG (DE) 2008-01-10 US disclosed
US-20070185038-A1 Regulation of mammalian keratinous tissue using skin care actives THE PROCTER & GAMBLE COMPANY 2007-08-09 US disclosed
US-20070185038-A1 Regulation of mammalian keratinous tissue using skin care actives THE PROCTER & GAMBLE COMPANY 2007-08-09 US disclosed
WO-2007062957-A1 MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING SYMRISE GMBH & CO. KG (DE) 2007-06-07 WO disclosed
WO-2007041548-A2 COMPOSITION FOR REGULATION OF MAMMALIAN KERATINOUS TISSUE THE PROCTER & GAMBLE COMPANY (US) 2007-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12564551-B2 Composition or oat extract comprising avenanthramide and β-glucan CUTA, HLA-A, OAT KDM1A 3410/4885MEN1 1127/4885KMT2A 2657/4885
US-20230129036-A1 AVENANTHRAMIDE COMPOSITIONS WITH IMPROVED SOLUBILITY COMPRISING 4-HYDROXYPHENONE HPD, CYP4A22, PAH KDM1A 2723/4885MEN1 2409/4885KMT2A 2584/4885
US-20090226537-A1 MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND ANTIDANDRUFF AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING H1-0, ASIC1, NHERF1 KDM1A 300/4885MEN1 1157/4885KMT2A 1286/4885
US-20230131993-A1 COMPOSITION COMPRISING AN AVENANTHRAMIDE OR AN ANALOGUE THEREOF WITH IMPROVED STABILITY OAT, PIGS, HLA-A KDM1A 3647/4885MEN1 376/4885KMT2A 2513/4885
US-20070185038-A1 Regulation of mammalian keratinous tissue using skin care actives CUTA, KDM7A, KDM2A KDM1A 14/4885MEN1 4064/4885KMT2A 124/4885
US-20080008660-A1 Antimicrobially active compounds for treating bad breath CAT, LPO, GPX1 KDM1A 1462/4885MEN1 1838/4885KMT2A 4210/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.