Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672123 | 0.85 | MAPKAPK2 (0.46) | ALDH1A1HPGDTSHRPARP1PARP2 | |
| SCHEMBL4673358 | 0.85 | MAOB (0.46) | ROCK2ALDH1A1PFKFB3TSHR | |
| SCHEMBL4670084 | 0.85 | ROCK2 (0.56) | MAPK1ATMPLA2G10PLA2G2AROCK2 | |
| SCHEMBL4673552 | 0.80 | MAPK1 (0.49) | MAPK1ATMROCK2MEN1KMT2A | |
| SCHEMBL4675102 | 0.79 | ALDH1A1 (0.42) | MAPK1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL4670479 | 0.79 | ALDH1A1 (0.39) | MAPK1ATMMEN1KMT2AALDH1A1 | |
| SCHEMBL4673671 | 0.78 | SIGMAR1 (0.52) | MEN1KMT2AALDH1A1 | |
| SCHEMBL4670081 | 0.77 | ADRB2 (0.42) | MAPK1ATMALDH1A1TSHROPRM1 | |
| Water SCHEMBL4673066 | 0.76 | ADRB2 (0.41) | MAPK1ATMALDH1A1TSHROPRM1 | |
| SCHEMBL4670624 | 0.76 | PARP15 (0.40) | MAPK1ATMALDH1A1TSHROPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054881-B1 | NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS | BAYER CORP (US) | 2008-07-30 | — | — | EP | disclosed |
| US-6903218-B2 | Sulfonamide substituted chroman derivatives | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-06-07 | — | — | US | disclosed |