Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8535843 | 0.89 | KEAP1 (0.59) | KEAP1HSD11B1FADS1ALDH1A1HDAC3 | |
| SCHEMBL1342200 | 0.86 | KEAP1 (0.56) | KEAP1HSD11B1FADS1ALDH1A1HDAC3 | |
| SCHEMBL5278682 | 0.84 | KEAP1 (0.54) | KEAP1HSD11B1FADS1ALDH1A1HDAC3 | |
| SCHEMBL4674613 | 0.83 | KEAP1 (0.53) | KEAP1HSD11B1FADS1HDAC3HDAC1 | |
| SCHEMBL4672823 | 0.81 | CES2 (0.50) | HSD11B1ALDH1A1MAPTNPY2RCES2 | |
| SCHEMBL11749982 | 0.79 | HTR1F (0.52) | KEAP1HSD11B1ALDH1A1HDAC3HDAC1 | |
| SCHEMBL4673461 | 0.79 | GAA (0.39) | HSD11B1ALDH1A1MAPTNPY2RCES2 | |
| SCHEMBL8105872 | 0.77 | KEAP1 (0.46) | KEAP1HSD11B1ALDH1A1HDAC3HDAC1 | |
| SCHEMBL8917695 | 0.75 | HSD11B1 (0.47) | HSD11B1ALDH1A1MEN1KMT2APIN1 | |
| SCHEMBL8105870 | 0.75 | ALDH1A1 (0.39) | KEAP1HSD11B1ALDH1A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-B2 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-04-09 | — | — | EP | disclosed |
| EP-0958287-B1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6376506-B1 | REACTING SULFAMOYL OXAZOLIDONE WITH (1,2,3,4)-TETRAHYDRO-BETA-CARBOLINE TO FORM INHIBITOR; USED TO TREAT ARTHRITIS, OSTEOPOROSIS, PERIODONTAL DISEASE, CARDIOVASCULAR DISEASES, MULTIPLE SCLEROSIS, AND TUMORS | SYNTEX (U.S.A.) LLC | 2002-04-23 | — | — | US | disclosed |