Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPY2R | P49146 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5278682 | 0.86 | KEAP1 (0.54) | KEAP1HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL1342200 | 0.84 | KEAP1 (0.56) | KEAP1HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL8535843 | 0.84 | KEAP1 (0.59) | KEAP1HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL11749982 | 0.83 | HTR1F (0.52) | KEAP1HSD11B1ALDH1A1KMT2AHDAC3 | |
| SCHEMBL4674613 | 0.79 | KEAP1 (0.53) | KEAP1HSD11B1MEN1KMT2AHDAC3 | |
| SCHEMBL8105870 | 0.78 | ALDH1A1 (0.39) | KEAP1HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL4674606 | 0.77 | KEAP1 (0.51) | KEAP1HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL9870334 | 0.77 | HSD11B1 (0.65) | HSD11B1ALDH1A1GAAKDM4EPOLB | |
| SCHEMBL8096357 | 0.76 | ALDH1A1 (0.56) | HSD11B1ALDH1A1KMT2AMAPTKDM4E | |
| SCHEMBL7920995 | 0.74 | HDAC3 (0.48) | KEAP1HSD11B1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-6130220-A | ENZYME INHIBITORS | SYNTEX (USA) INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |